Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Amino acid sequence (1)
- Amino acids (1)
- Bacteria (1)
- Bacteriophage lambda (1)
- Brief communication (1)
-
- Brief communications (1)
- Drugs (1)
- Ecological effects (1)
- Evolution (1)
- Experimental evolution (1)
- Experiments (1)
- Gain of function (1)
- Gene mutations (1)
- Genetic (1)
- Genetics (1)
- Genome epidemiology (1)
- Host shift (1)
- J protein (1)
- Laboratories (1)
- Mechanisms (1)
- Molecular (1)
- Mutation (1)
- Mutations (1)
- Natural variation (1)
- Pharmacology (1)
- Phylogeny (1)
- Proteins (1)
- Residues (1)
- Resistance (1)
- Selection (1)
Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
Better Living Through Chemistry: Addressing Emerging Antibiotic Resistance, Nathan P. Coussens, Ashley L. Molinaro, Kayla J. Culbertson, Tyler Peryea, Gergely Zahoránszky-Köhalmi, Matthew D. Hall, Dayle A. Daines
Better Living Through Chemistry: Addressing Emerging Antibiotic Resistance, Nathan P. Coussens, Ashley L. Molinaro, Kayla J. Culbertson, Tyler Peryea, Gergely Zahoránszky-Köhalmi, Matthew D. Hall, Dayle A. Daines
Biological Sciences Faculty Publications
The increasing emergence of multidrug-resistant bacteria is recognized as a major threat to human health worldwide. While the use of small molecule antibiotics has enabled many modern medical advances, it has also facilitated the development of resistant organisms. This minireview provides an overview of current small molecule drugs approved by the US Food and Drug Administration (FDA) for use in humans, the unintended consequences of antibiotic use, and the mechanisms that underlie the development of drug resistance. Promising new approaches and strategies to counter antibiotic-resistant bacteria with small molecules are highlighted. However, continued public investment in this area is critical …
Gain-Of-Function Experiments With Bacteriophage Lambda Uncover Residues Under Diversifying Selection In Nature, Rohan Maddamsetti, Daniel T. Johnson, Stephanie J. Spielman, Katherine L. Petrie, Debora S. Marks, Justin R. Meyer
Gain-Of-Function Experiments With Bacteriophage Lambda Uncover Residues Under Diversifying Selection In Nature, Rohan Maddamsetti, Daniel T. Johnson, Stephanie J. Spielman, Katherine L. Petrie, Debora S. Marks, Justin R. Meyer
Biological Sciences Faculty Publications
Viral gain-of-function mutations frequently evolve during laboratory experiments. Whether the specific mutations that evolve in the lab also evolve in nature and whether they have the same impact on evolution in the real world is unknown. We studied a model virus, bacteriophage λ, that repeatedly evolves to exploit a new host receptor under typical laboratory conditions. Here, we demonstrate that two residues of λ’s J protein are required for the new function. In natural λ variants, these amino acid sites are highly diverse and evolve at high rates. Insertions and deletions at these locations are associated with phylogenetic patterns indicative …