Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Bisphenol A (1)
- Coronavirus (1)
- Endocrine-Disrupting Chemical (1)
- Endothelial cells (1)
- Estrogen Receptor-β signaling pathway (1)
-
- Fetal Development (1)
- Fetal Exposure (1)
- Glucocorticoid Signaling Pathway (1)
- Lipids (1)
- Lung Disease (1)
- Lung Maturation (1)
- Membrane protein (1)
- Molecular farming (1)
- NF-κB signaling pathway (1)
- Niacin (1)
- Nicotiana benthamiana (1)
- Plant biotechnology (1)
- Reduced Lung Function (1)
- Vascular biology (1)
- Virus-like particle (1)
- Publication
- Publication Type
Articles 1 - 3 of 3
Full-Text Articles in Medicine and Health Sciences
Producing A Subunit Vaccine For Porcine Epidemic Diarrhea Virus, Zayn Khamis
Producing A Subunit Vaccine For Porcine Epidemic Diarrhea Virus, Zayn Khamis
Electronic Thesis and Dissertation Repository
Porcine epidemic diarrhea virus (PEDv) causes disease and mortality to piglets worldwide. Most vaccines used to combat the disease have been ineffective live attenuated virus vaccines. The goal of this project was to produce a plant-made subunit vaccine based off the membrane protein of the virus. This is the first time this protein has been produced in plants. An elastin-like polypeptide fusion membrane protein accumulated up to 0.8 mg/g of fresh leaf weight when transiently expressed in Nicotiana benthamiana. Virus-like particles were also produced for the first time for PEDv, and were able to form with just the membrane …
Effects Of Prenatal Exposure To Bisphenol A On Fetal Lung Development, Ayten Hijazi
Effects Of Prenatal Exposure To Bisphenol A On Fetal Lung Development, Ayten Hijazi
Electronic Thesis and Dissertation Repository
Prenatal exposure to bisphenol A (BPA), one of the most prevalent endocrine disrupting chemicals, is associated with lung dysfunction and diseases in later life. However, it is unknown if this association has a fetal origin. In this thesis, a series of in vivo and in vitro experiments were conducted to determine the effects of prenatal exposure to BPA on fetal lung development, and define the underlying molecular mechanisms. Environmentally relevant doses of BPA were administered to pregnant mice via diet from embryonic day (E) 7.5 to 18.5. Fetal lungs were analyzed at E18.5 for changes in structure and expression of …
Gene Expression Microarray Data From Human Microvascular Endothelial Cells Supplemented With A Low Concentration Of Niacin, Nica M. Borradaile, Jennifer M. Hughes-Large
Gene Expression Microarray Data From Human Microvascular Endothelial Cells Supplemented With A Low Concentration Of Niacin, Nica M. Borradaile, Jennifer M. Hughes-Large
Physiology and Pharmacology Publications
The systemic lipid modifying drug, niacin, can directly improve human microvascular endothelial cell angiogenic function under lipotoxic conditions, possibly through activation of niacin receptors [1]. Here we provide accompanying data collected using Affymetrix GeneChip microarrays to identify changes in gene expression in human microvascular endothelial cells treated with 10 μM niacin. Statistical analyses of robust multi-array average (RMA) values revealed that only 16 genes exhibited greater than 1.3-fold differential expression. Of these 16, only 5 were identified protein coding genes, while 3 of the remaining 11 genes appeared to be small nuclear/nucleolar RNAs. Altered expression of EFCAB4B, …