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University of Texas Rio Grande Valley
Health & Biomedical Sciences Faculty Publications and Presentations
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Increased Plasma Levels Of The Th2 Chemokine Ccl18 Associated With Low Cd4+ T Cell Counts In Hiv-1-Infected Patients With A Suppressed Viral Load, Prashant Malhotra, Patrick Haslett, Barbara Sherry, David H. Shepp, Paul Barber, Jonathan Abshier, Upal Roy, Helena Schmidtmayerova
Increased Plasma Levels Of The Th2 Chemokine Ccl18 Associated With Low Cd4+ T Cell Counts In Hiv-1-Infected Patients With A Suppressed Viral Load, Prashant Malhotra, Patrick Haslett, Barbara Sherry, David H. Shepp, Paul Barber, Jonathan Abshier, Upal Roy, Helena Schmidtmayerova
Health & Biomedical Sciences Faculty Publications and Presentations
The chemokine (C-C motif) chemokine ligand 18 (CCL18) is a structural homolog of CCL3 primarily produced by monocyte-derived cells with an M2 phenotype. Elevated levels of CCL18 have been observed in several diseases associated with malignancies and chronic inflammation. The role of CCL18 in Human Immunodeficiency Virus (HIV-1) infection remains unknown. We analyzed expression levels of T helper cell-mediated (TH2) chemokines CCL18, CCL17, and CCL22 by ELISA in plasma collected from HIV-1-infected and healthy donors. In HIV-1-infected individuals, plasma viral loads were monitored by NucliSense HIV-1 QT assay and T cell counts and expression of the activation marker CD38 were …