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- Dietary supplements (2)
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- Adverse effects; cannabinoid addiction; cannabinoids; chronic pain; efficacy; medical marijuana; pain management (1)
- Aged; Cognition -- drug effects; Dementia -- etiology; Proton Pump Inhibitors -- adverse effects; Vitamin B 12 Deficiency -- complications (1)
- Alzheimer Disease -- drug therapy; Alzheimer Disease -- prevention & control; Donepezil -- adverse effects; Donepezil -- therapeutic use (1)
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- Anemia -- chemically induced; Drug Monitoring; Hypoglycemic Agents -- adverse effects; Metformin -- adverse effects; Vitamin B 12 Deficiency -- complications (1)
- Antidepressive Agents -- therapeutic use; Costs and Cost Analysis; Depressive Disorder (1)
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- Glucagon-like peptide-1, sulfonylurea, diabetes mellitus, second line treatment (1)
- Gonorrhea, Chlamydia, EPT, STI, Azithromycin, Cefixime, Gemifloxacin, Expedited Partner Therapy, Sexually Transmitted Disease, Ceftriaxone, Partner Notification, Partner Treatment (1)
- Major -- drug therapy; Pharmacogenomic Testing; Treatment Outcome (1)
- Major -- genetics; Depressive Disorder (1)
- Marijuana & Medical Marijuana; Cannabis & Cannabinoid; Acute & Chronic Pain; Opiates & Opioids; Addiction & Addiction Profile; Mortality; Opioid Deaths; Marijuana Deaths; Quality of Life (1)
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Articles 1 - 16 of 16
Full-Text Articles in Medicine and Health Sciences
Comparison Of Rivaroxaban And Warfarin In The Prevention Of Recurrent Venous Thromboembolism, Philip Joel Heiden
Comparison Of Rivaroxaban And Warfarin In The Prevention Of Recurrent Venous Thromboembolism, Philip Joel Heiden
Physician Assistant Scholarly Project Papers
The purpose of this systematic literature review is to determine the efficacy and safety of rivaroxaban (Xarelto) compared to warfarin (Coumadin), for the long term prophylaxis of recurrent venous thromboembolism (VTE). Rivaroxaban was chosen as the primary representative of factor Xa inhibitors because of its simplistic once a day dosing regimen. The PubMed database was extensively searched, using a variety of key terms, from September 10 to November 30, 2018. Works chosen include propensity-matched cohorts, retrospective studies, systematic reviews, and meta-analyses. All of which were published within the last 10 years; sources dated prior to 10 years were excluded. Studies …
The Impact Of Medical Marijuana On The Opioid Crisis, Carl David Estep
The Impact Of Medical Marijuana On The Opioid Crisis, Carl David Estep
Physician Assistant Scholarly Project Papers
In light of the current opioid crisis, research is needed to identify alternative treatments for acute and chronic pain. With medical marijuana being made available by rapidly changing state laws, it is prudent to identify what role it may play in pain control. This comprehensive literature review was conducted to determine what is known as to the effectiveness of medical marijuana, cannabis, or cannabinoids for treating acute and chronic pain as compared to prescription opiates. An additional comparison was also made between the addictive properties and adverse effects of medical marijuana and prescription opiates. The final parameter evaluated was the …
Glucagon-Like Peptide-1s Compared To Sulfonylureas In The Treatment Of Adults Diagnosed With Type Ii Diabetes Mellintus In Primary Care, Tracy Kirchner
Glucagon-Like Peptide-1s Compared To Sulfonylureas In The Treatment Of Adults Diagnosed With Type Ii Diabetes Mellintus In Primary Care, Tracy Kirchner
Physician Assistant Scholarly Project Papers
Type II diabetes mellitus (T2DM) is a prevalent disease in our country. Bullard et al. (2018) report approximately 21 million adults have T2DM in the United States. “The total estimated cost of diagnosed diabetes in 2017 is $327 billion, including $237 billion in direct medical costs and $90 billion in reduced productivity” (Yang et al., 2018). Treatment of T2DM is individualized to each patient based on their co-morbidities, fiscal responsibility, and route of administration options. Sulfonylureas and Glucagon-like Peptide-1s (GLP-1) are two classes of antidiabetic drugs that are available for use as second line treatment options after metformin. This review …
Expedited Partner Therapy Using Oral Cefixime And Oral Azithromycin For Gonorrheal And Chlamydial Infections Among Adult Outpatients In The United States, Nicholas Coburn-Pierce
Expedited Partner Therapy Using Oral Cefixime And Oral Azithromycin For Gonorrheal And Chlamydial Infections Among Adult Outpatients In The United States, Nicholas Coburn-Pierce
Physician Assistant Scholarly Project Papers
Sexually transmitted infections (STI) such as Neisseria Gonorrhoeae and Chlamydia Trachomatis pose a challenge to the healthcare system worldwide. Treating sexual partners is as crucial to controlling the spread of these infections as treating index patients. However, because of problems associated with stigma, reaching affected populations, and ensuring follow-up, unique solutions are require to ensure partners receive treatment. One solution is Expedited Partner Therapy (EPT). EPT refers to treating patients, and providing necessary medication for both patient and partner. Current recommendations are for oral doses one gram of azithromycin and 400 milligrams of cefixime. This literature review looked at thirteen …
Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt
Parenteral Ascorbic Acid For Treatment Of Sepsis, Lindsey Hiatt
Physician Assistant Scholarly Project Papers
Sepsis kills nearly 1 million people each year in the United States and sepsis-related hospitalizations cost approximately $24 billion annually (Paoli, Reynolds, Sinha, Gitlin, & Crouser, 2018). Current treatment guidelines are limited to targeted antibiotics and hemodynamic support. While antibiotics are the definitive treatment to eradicate the infectious pathogen, there are currently no standard-of-care treatments that consistently and successfully attenuate the damage sustained to the body by its own inflammatory response to infection. Many different treatments have been trialed and failed to show improved outcomes. Vitamin C, or ascorbic acid, has long been associated with supporting immune function, and has …
The Impact Of Medical Marijuana On The Opioid Crisis, Carl David Eastep
The Impact Of Medical Marijuana On The Opioid Crisis, Carl David Eastep
Physician Assistant Scholarly Project Posters
• The opioid crisis dictates the need for research into alternative treatments for acute and chronic pain.
• Comprehensive literature review was conducted to determine if medical marijuana might play a role in the treatment of acute and chronic pain.
• The addiction profiles of medical marijuana and prescription opiates were compared along with the adverse effects and quality of life.
• No use for medical marijuana for the treatment of acute pain.
• Likely some benefits from medical marijuana for chronic pain.
• Addictive profile
• Marijuana – marijuana withdrawal syndrome.
• Prescription Opiates – highly addictive
• Adverse …
Use Of Beta-Antagonists Or Hmg-Coa Reductase Inhibitors For Cardioprotection During Chemotherapy In Oncology Patients, Nicole Streich
Use Of Beta-Antagonists Or Hmg-Coa Reductase Inhibitors For Cardioprotection During Chemotherapy In Oncology Patients, Nicole Streich
Physician Assistant Scholarly Project Posters
Over the years, oncologists are better able to fight cancer and have increased cancer survival, but we are also finding that these lifesaving therapies can affect the heart and other parts of the body in a negative way. Chemotherapy is excellent at destroying cancer cells, but it also causes collateral damage to other healthy cells. There are certain chemotherapeutic agents that are known to cause cardiotoxicity. Currently we are monitoring the heart function of the patients who are receiving these cardiotoxic drugs prior to starting the chemotherapy as well as during and after treatment. However, there are currently no recommendations …
The Safety And Efficacy Of Creatine Supplementation In The General Public, Cody Baxter
The Safety And Efficacy Of Creatine Supplementation In The General Public, Cody Baxter
Physician Assistant Scholarly Project Posters
The purpose of this study was to determine whether supplementation with creatine monohydrate is efficacious beyond the realm of its most popular use, which is in athletics. This study investigated the safety of creatine supplementation in the general population. References were collected through a review of PubMed and Scopus databases. Initial keywords searched were creatine supplementation and creatine safety. Where possible, trials with human subjects were utilized. Studies focused on creatine’s effects in athletes or weightlifting parameters were eliminated. Topics were further narrowed down by conditions with the most amount of research and medical concerns recognized as common to primary …
The Efficacy And Safety Of Creatine Supplementation In The General Population, Cody Baxter
The Efficacy And Safety Of Creatine Supplementation In The General Population, Cody Baxter
Physician Assistant Scholarly Project Papers
The purpose of this study was to determine whether supplementation with creatine monohydrate is efficacious beyond the realm of its most popular use, which is in athletics. This study investigated the safety of creatine supplementation in the general population. References were collected through a review of PubMed and Scopus databases. Initial keywords searched were creatine supplementation and creatine safety. Where possible, trials with human subjects were utilized. Studies focused on creatine’s effects in athletes or weightlifting parameters were eliminated. Topics were further narrowed down by conditions with the most amount of research and medical concerns recognized as common to primary …
Cannabinoid Therapy In Chronic Pain Management, Breanna Joy Privratsky,
Cannabinoid Therapy In Chronic Pain Management, Breanna Joy Privratsky,
Physician Assistant Scholarly Project Papers
In 1996, the state of California was the first in the union to allow for the use of medical marijuana. Since then, 28 more states have enacted similar laws (National Conference of State Legislatures, [NCSL], 2017). With the ever-growing opiate problem that has now been classified as an epidemic by the Centers for Disease Control and Prevention, medical marijuana could be a viable alternative to this problem. As of 2014, the CDC reported opioid deaths were up 369%, which is more than 91 deaths per day from overdose (Centers for Disease Control, [CDC], 2017). The purpose of this study is …
Cannabinoid Therapy In Chronic Pain Management, Breanna Joy Privratsky
Cannabinoid Therapy In Chronic Pain Management, Breanna Joy Privratsky
Physician Assistant Scholarly Project Posters
In 1996, the state of California was the first in the union to allow for the use of medical marijuana. Since then, 28 more states have enacted similar laws (National Conference of State Legislatures, [NCSL], 2017). With the ever-growing opiate problem that has now been classified as an epidemic by the Centers for Disease Control and Prevention, medical marijuana could be a viable alternative to this problem.
As of 2014, the CDC reported opioid deaths were up 369%, which is more than 91 deaths per day from overdose (Centers for Disease Control, [CDC], 2017). The purpose of this study is …
Metformin And Vitamin B12 Deficiency: Consequences And Patient Monitoring, Kathryn Dietz
Metformin And Vitamin B12 Deficiency: Consequences And Patient Monitoring, Kathryn Dietz
Physician Assistant Scholarly Project Posters
• The incidence of type 2 diabetes has been increasing at a rapid rate in the United States.
• Metformin is recommended as the first line treatment to be started at the time of diagnosis in all patients without contraindications and has been associated with vitamin B12 deficiency.
• There are currently no clinical guidelines for the routine monitoring of B12 levels in this population.
• The purpose of this scholarly project is to determine if there are consequences of this deficiency and to make recommendations for screening patients.
• It includes current research that focuses on the pathophysiology of …
The Association Between Antipsychotic Medication And Weight Gain, Brian Steen
The Association Between Antipsychotic Medication And Weight Gain, Brian Steen
Physician Assistant Scholarly Project Posters
• Antipsychotic medications are utilized for patients with many mental health problems including schizophrenia, attention deficit hyperactivity disorder, autism, bipolar mania, and psychotic depression. The antipsychotic medications treat the symptoms associated with these mental health disorders.
• Antipsychotic medications, while being efficacious to these symptoms, can have unwanted side effects, including weight gain. The purpose of this study was to determine if there is a strong relationship with antipsychotic medication use and weight gain.
• The review of literature was conducted with an online search of Cochrane, PubMed, and PsycInfo for journal articles, research studies, and other scholarly reviews. Articles …
Pharmacogenetic Testing In The Treatment Of Major Depressive Disorder, Brianna Strube
Pharmacogenetic Testing In The Treatment Of Major Depressive Disorder, Brianna Strube
Physician Assistant Scholarly Project Posters
• Major depressive disorder (MDD) is one of the most prevalent psychiatric disorders in the United States and is a large cause of disability. Antidepressants take weeks/months to become effective which can lead to noncompliance. Treatment has a high failure rate which increases medical costs and leads to decreased patient outcomes.
• Pharmacogenetic testing is the practice of analyzing genetic differences to predict a patient’s response to medications to improve efficacy and decrease adverse side effects. The purpose of this study was to investigate if pharmacogenetic-guided treatment, specifically in the use of antidepressants in MDD, has resulted in improved patient …
Association Between Proton Pump Inhibitor Use & Dementia: A Two-Fold Approach, Lisa Steers
Association Between Proton Pump Inhibitor Use & Dementia: A Two-Fold Approach, Lisa Steers
Physician Assistant Scholarly Project Posters
An observational study of data derived from the German Study on Aging, Cognition and Dementia indicated that proton pump inhibitor use was associated with dementia risk (Benmassaoud, McDonald, & Lee, 2016). The purpose of this study is to explore a two-fold approach between proton pump inhibitor use and dementia. This two-fold approach will first investigate the association between dementia and proton pump inhibitor use and secondly, the proposed pathophysiology behind it. This approach to proton pump inhibitor use and dementia will allow for providers to utilize the association and make decisions to avoid chronic proton pump inhibitor use in effort …
Use Of Donepezil In Alzheimer's Disease: Suggested Practice Guidelines, Tamara Berg
Use Of Donepezil In Alzheimer's Disease: Suggested Practice Guidelines, Tamara Berg
Physician Assistant Scholarly Project Posters
Alzheimer’s disease (AD) is the cause of 60-80% of dementia (2014 Alzheimer’s disease, 2014). AD is estimated to affect over 5 million people over age 65 in the US (2014 Alzheimer’s disease, 2014). With the onset of baby boomers reaching the age of 65 and increased longevity it is estimated that 16 million persons will have Alzheimer’s by 2050. Eighty two percent of persons with AD are over age 85. In 2014 AD is the 6th leading cause of death and the highest cost disease in the US. (2014 Alzheimer’s disease, 2014)
The predicted increase in prevalence and incidence of …