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Full-Text Articles in Medicine and Health Sciences
A 31p, 13c, And 1h Nmr Study Of The Direct Interaction Of Cocaine Hc1 And Magnesium Atp, Gene Lee Bangs, Roger M. Hawk, Debi Patangia
A 31p, 13c, And 1h Nmr Study Of The Direct Interaction Of Cocaine Hc1 And Magnesium Atp, Gene Lee Bangs, Roger M. Hawk, Debi Patangia
Journal of the Arkansas Academy of Science
In vivo 31P NMR studies recently have shown that cocaine causes an imbalance of the free magnesium in the brain which results in pH lowering, ischemia, and even death. This direct interaction with the free Mg+2 inthe brain also affects the Ca+2 balance which controls arterial and vascular contraction. This research has addressed the mechanism of the cocaine interaction withmagnesium adenosine 5-triphosphate (ATP) using 31P, 13C, and 1H NMR using a Bruker 200 MHz nuclear magnetic resonance (NMR) system. Data are presented and discussed which shows that cocaine and ATP form a complex species which directly affects the NMR spectra.
Conformational Studies Of Ortho- And Meto-Isomers And Methyl, Dimethyl, And Chloro Ortho-Substituted Analogues Of Dantrolene Using Ab Initio Scf-Mo Procedures, Lori L. Rayburn, Amber D. Climer, Jerry A. Darsey, Ali U. Shaikh, Kevin S. Robertson, E. Kim Fifer
Conformational Studies Of Ortho- And Meto-Isomers And Methyl, Dimethyl, And Chloro Ortho-Substituted Analogues Of Dantrolene Using Ab Initio Scf-Mo Procedures, Lori L. Rayburn, Amber D. Climer, Jerry A. Darsey, Ali U. Shaikh, Kevin S. Robertson, E. Kim Fifer
Journal of the Arkansas Academy of Science
The conformation of the nitro group of nitroaromatic compounds relative to the aromatic ringsystem is suggested to affect their metabolic activation and mutagenicity. We have recently showed the nitrophenylfuran skeletal muscle relaxant, dantrolene, tobe a potent mutagen inSalmonella. Synthesis of or^o-substituted analogues of dantrolene was achieved in an effort to alter the conformation of the nitro group ina manner that willdecrease the mutagenicity. Using ab initio techniques we investigated the minimum energy conformation of the nitro group of dantrolene (/mitro) and its o-and mnitro isomers as well as the nitro group conformation of dantrolene's ortho- mono- and di- substituted analogues. …