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The British University in Egypt
Calixarenes; Dissolution testing; In-line monitoring; Potentiometric sensors; Sitagliptin
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Full-Text Articles in Medicine and Health Sciences
In-Line Monitoring Of Sitagliptin Dissolution Profile From Tablets Utilizing An Eco-Friendly Potentiometric Sensor, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, Maha A. Hegazy
In-Line Monitoring Of Sitagliptin Dissolution Profile From Tablets Utilizing An Eco-Friendly Potentiometric Sensor, Shereen Mowaka, Manar M. Elhassan, Amr M. Mahmoud, Maha A. Hegazy
Pharmacy
Sitagliptin, an oral antidiabetic drug, is an effective medication for lowering blood glucose level either as monotherapy or in combination with other antidiabetic drugs. This work aims for the fabrication of a potentiometric sensor for sitagliptin detection. The sensor was designed by doping the polyvinyl chloride polymeric ion-selective membrane with calix[4]arene as an ionophore which highly improved the linearity range (1 × 10−6—1 × 10−2 M), sensitivity, selectivity and limit of detection (6.3 × 10−7 M) compared to ionophore-free membrane. The method was then validated according to the International Council for Harmonization (ICH) guidelines. The sensor was successfully employed to …