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Biological Evaluation Of Cyclooxygenase-2 Inhibitor Nimesulide Derivatives As Anti-Agents, Amandeep Singh, Snigdha Chennamaneni

Undergraduate Research Posters 2012

Cyclooxygenase-2 (COX-2) inhibitor nimesulide inhibits the proliferation of various types of cancer cells mainly via COX-2 independent mechanisms, which makes it a good lead compound for anti-cancer drug development. A series of new nimesulide analogs were evaluated with cell proliferation assay based on a non-small lung cancer cell line H292. The results showed that several derivatives were very active to against H292 cell growth with IC50s of sub nano mole. These results suggest the possibility of using these nimesulide derivatives as chemo preventive agents.