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Full-Text Articles in Medicine and Health Sciences
The Role Of Mmp9 In Satellite Cell Activation After Increased Activity, Mike H.M.H. Pang, Jung A. Kim, Gary E. Mccall, Ryan S. Mehan, J-P Hyatt
The Role Of Mmp9 In Satellite Cell Activation After Increased Activity, Mike H.M.H. Pang, Jung A. Kim, Gary E. Mccall, Ryan S. Mehan, J-P Hyatt
Summer Research
The unique adaptive ability of skeletal muscle to meet functional demands is exemplified in its response to exercise. Though little is known about the molecular mechanisms that regulate this plasticity, the extracellular matrix (ECM) is believed to play a large role. The basal lamina is a specialized layer of ECM that lies in direct contact with the cell membrane of muscle fibers and facilitates environment-to-cell interactions. Matrix metalloproteinase-9 (MMP-9) is an enzyme in the basal lamina that regulates much of these adaptive processes. During exercise, the regenerative process of damaged tissue requires the activation of muscle-specific stem cells known as …
Prl-1’S Inhibition Of Drosophila Melanogaster Cell Growth Is Dependent On The Caax Membrane Localization Domain, Bryce Bunn
Summer Research
The human body exhibits a spectacular collection of cells, integrated with seemingly infinite communication techniques and control mechanisms. Cancer’s disastrous influence on this complex system proves difficult to map. The shotgun clinical trial testing of human cancers has provided a feast of proteins suspected of encouraging cancerous cell behavior. One, Phosphatase of Regenerating Liver protein-1 (PRL-1), has been found to encourage cancerous growth while localizing in a variety of subcellular locations within metastasizing human tumor cells. However, PRL-1 has also been found to act as a tumor suppressor while localizing to the cell membrane in mammalian and insect models. In …
Single Cell Wound Healing In Drosophila Melanogaster Embryos, John Rosasco
Single Cell Wound Healing In Drosophila Melanogaster Embryos, John Rosasco
Summer Research
The role of contractile actin and myosin filaments filaments and the links they form with other proteins are vitally important to single cell wound healing, Which occurs in synctial Drosophila embryos as well as in vertebrates. Previous work by Wayne Rickoll has concentrated on determining the orientations of actin during wound healing during dorsal closure in Drosophila, a morphogenetic process in which epidermal cells extend to cover the embryonic gut during development. Transmission electron microscope analysis of cells undergoing dorsal closure revealed that actin is oriented parallel and perpendicular to the leading edge of the wound. Based on this …