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Full-Text Articles in Medicine and Health Sciences
Estimating Controlled Direct Effects Of Restrictive Feeding Practices In The `Early Dieting In Girls' Study, Yeying Zhu, Debashis Ghosh, Donna L. Coffman, Jennifer S. Williams
Estimating Controlled Direct Effects Of Restrictive Feeding Practices In The `Early Dieting In Girls' Study, Yeying Zhu, Debashis Ghosh, Donna L. Coffman, Jennifer S. Williams
Debashis Ghosh
In this article, we examine the causal effect of parental restrictive feeding practices on children’s weight status. An important mediator we are interested in is children’s self-regulation status. Traditional mediation analysis (Baron and Kenny, 1986) applies a structural equation modelling (SEM) approach and decomposes the intent-to-treat (ITT) effect into direct and indirect effects. More recent approaches interpret the mediation effects based on the potential outcomes framework. In practice, there often exist confounders that jointly influence the mediator and the outcome. Inverse probability weighting based on propensity scores are used to adjust for confounding and reduce the dimensionality of confounders simultaneously. …
Semiparametric Analysis Of Recurrent Events: Artificial Censoring, Truncation, Pairwise Estimation And Inference, Debashis Ghosh
Semiparametric Analysis Of Recurrent Events: Artificial Censoring, Truncation, Pairwise Estimation And Inference, Debashis Ghosh
Debashis Ghosh
The analysis of recurrent failure time data from longitudinal studies can be complicated by the presence of dependent censoring. There has been a substantive literature that has developed based on an artificial censoring device. We explore in this article the connection between this class of methods with truncated data structures. In addition, a new procedure is developed for estimation and inference in a joint model for recurrent events and dependent censoring. Estimation proceeds using a mixed U-statistic based estimating function approach. New resampling-based methods for variance estimation and model checking are also described. The methods are illustrated by application to …
Long-Term Consequences Of The Delay Between Virologic Failure Of Highly Active Antiretroviral Therapy And Regimen Modification, Maya L. Petersen, Mark J. Van Der Laan, Napravnik Sonia, Joseph J. Eron, Richard G. Moore, Steven G. Deeks
Long-Term Consequences Of The Delay Between Virologic Failure Of Highly Active Antiretroviral Therapy And Regimen Modification, Maya L. Petersen, Mark J. Van Der Laan, Napravnik Sonia, Joseph J. Eron, Richard G. Moore, Steven G. Deeks
Maya Petersen
Objectives: Current treatment guidelines recommend immediate modification of antiretroviral therapy in HIV-infected individuals with incomplete viral suppression. These recommendations have not been tested in observational studies or large randomized trials. We evaluated the consequences of delayed modification following virologic failure. Design/methods: We used prospective data from two clinical cohorts to estimate the effect of time until regimen modification following first regimen failure on all-cause mortality. The impact of regimen type was also assessed. As the effect of delayed switching can be confounded if patients with a poor prognosis modify therapy earlier than those with a good prognosis, we used a …