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Full-Text Articles in Medicine and Health Sciences
A Systematic Review And Meta-Analysis On The Efficacy Of Stem Cell Therapy On Bone Brittleness In Mouse Models Of Osteogenesis Imperfecta, Lauren Battle, Shoshana Yakar, Alessandra Carriero
A Systematic Review And Meta-Analysis On The Efficacy Of Stem Cell Therapy On Bone Brittleness In Mouse Models Of Osteogenesis Imperfecta, Lauren Battle, Shoshana Yakar, Alessandra Carriero
Publications and Research
There is no cure for osteogenesis imperfecta (OI), and current treatments can only partially correct the bone phenotype. Stem cell therapy holds potential to improve bone quality and quantity in OI. Here, we conduct a systematic review and meta-analysis of published studies to investigate the efficacy of stem cell therapy to rescue bone brittleness in mouse models of OI. Identified studies included bone marrow, mesenchymal stem cells, and human fetal stem cells. Effect size of fracture incidence, maximum load, stiffness, cortical thickness, bone volume fraction, and raw engraftment rates were pooled in a random-effects meta-analysis. Cell type, cell number, injection …
Use Of 3d-Printed Surgical Spoons Compared To Other Cystotomy Methods In Dogs, Davina D'Angelo
Use Of 3d-Printed Surgical Spoons Compared To Other Cystotomy Methods In Dogs, Davina D'Angelo
Animal Science Undergraduate Honors Theses
Bladder stones, also known as uroliths, are not an uncommon condition in domestic dogs. To remove these uroliths, which occur in various sizes, shapes, and compositions, veterinarians will perform a surgical procedure called a cystotomy. A cystotomy consists of creating a small incision into the lumen of the urinary bladder and the utilization of various methods to extract the uroliths. For general veterinary practitioners, the laparoscopic-assisted technique is unavailable. As a result, the methods available for urolith extraction are often limited to flushing the stones out by inserting a urinary catheter through the urinary tract and the use of off-label …
The Role Of Spider Silk In Peripheral Nerve Regeneration, Langston Forbes-Jackson
The Role Of Spider Silk In Peripheral Nerve Regeneration, Langston Forbes-Jackson
Undergraduate Honors Theses
Spider silk neural guidance channels (NGCs) are highly important innovations in the field of regenerative medicine. This paper will discuss the evidence in the literature that supports their function in regenerative medicine and provide a template for future experiments in the field. While many studies within the past 15 years have demonstrated the validity of spider silk as a scaffold for peripheral nerve regeneration, the molecular mechanics that facilitate regeneration are poorly understood. An emphasis on using silk from orb weaving spiders in particular may have caused researchers to overlook other spiders whose silk could prove to have vastly different …
Catechol-Containing Copolymers As An Active Ingredient For Denture Adhesives, Vincent Ying Wun Kong
Catechol-Containing Copolymers As An Active Ingredient For Denture Adhesives, Vincent Ying Wun Kong
Electronic Thesis and Dissertation Repository
Moisture inside the mouth adds challenge to making denture adhesives formulations. Some formulations have zinc to enhance adhesion on wet skin despite knowing the health hazards. Inspired by mussel foot proteins’ catechol unit’s strong underwater adhesion, nine catechol-containing copolymers (P1A-P3C) were synthesized by free radical polymerization of 3,4-dimethoxystyrene (3,4- DMS) with different styrene derivatives followed by deprotection. P1A-P3C were used to make Fn(P)-C-PBS denture adhesive formulations which had suitable shear stresses around ≥ 5 kPa satisfying ISO 10873. In-situ NMR studies of free radical polymerization of 3,4 - DMS and styrene derivatives allowed computation of their reactivity ratios showing all …
In Vitro Analyses Of The Contributions Of The Hip Capsule To Joint Biomechanics, Emma Donnelly
In Vitro Analyses Of The Contributions Of The Hip Capsule To Joint Biomechanics, Emma Donnelly
Electronic Thesis and Dissertation Repository
Optimal management of the hip capsule during arthroscopic surgery has not been established. The impact of incisions made to the capsule during minimally invasive procedures on joint biomechanics, and whether repair provides any benefit, continue to be debated. The effectiveness of capsular repair to restore native kinematics may be insufficient. Therefore, a better understanding of joint behavior during various capsule conditions is needed. A new robotic system was used to analyze the effect of progressive capsulotomy incision and repairs on the behavior of a normal hip within range of motion (ROM) limits with respect to the intact joint. Complete repairs …