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Full-Text Articles in Medicine and Health Sciences
Inhibitory Or Excitatory? Optogenetic Interrogation Of The Functional Roles Of Gabaergic Interneurons In Epileptogenesis, Hui Ye
Biology: Faculty Publications and Other Works
Alteration in the excitatory/inhibitory neuronal balance is believed to be the underlying mechanism of epileptogenesis. Based on this theory, GABAergic interneurons are regarded as the primary inhibitory neurons, whose failure of action permits hyperactivity in the epileptic circuitry. As a consequence, optogenetic excitation of GABAergic interneurons is widely used for seizure suppression. However, recent evidence argues for the context-dependent, possibly “excitatory” roles that GABAergic cells play in epileptic circuitry. We reviewed current optogenetic approaches that target the “inhibitory” roles of GABAergic interneurons for seizure control. We also reviewed interesting evidence that supports the “excitatory” roles of GABAergic interneurons in epileptogenesis. …
Utilizing Modular Labs In Human Anatomy And Physiology: Lessons Learned From A First Time Experience, Jennifer Zitzner
Utilizing Modular Labs In Human Anatomy And Physiology: Lessons Learned From A First Time Experience, Jennifer Zitzner
Biology: Faculty Publications and Other Works
Anatomy and physiology laboratory experiences build upon concepts that are presented in the lecture part of the course. Our anatomy and physiology laboratory class meets weekly for approximately three hours and includes a compilation of activities that are to be completed during the laboratory period. While exercises are built off of topics presented in lecture and predominantly hands-on in nature, many students were not taking advantage of the self-directed learning experiences, especially those employing anatomical models. Some students were content to simply take photographs of models with their cell phones and complete only the graded portions of the laboratory assignment …