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Articles 1 - 4 of 4
Full-Text Articles in Medicine and Health Sciences
Construction And Mutagenesis Of Ssv1 Mutants In Extreme Viruses, Lou Ann F. O'Connor, Jono Abshier, Kenneth M. Stedman
Construction And Mutagenesis Of Ssv1 Mutants In Extreme Viruses, Lou Ann F. O'Connor, Jono Abshier, Kenneth M. Stedman
Student Research Symposium
Archaeal viruses with unique structures such as spindle-shaped virions are found abundantly in extreme environments like geothermal hot springs around the world. Among all spindle-shaped viruses, the model Sulfolobus Spindle-shaped Virus 1 (SSV1) is best studied. Creating the lemon-shaped or spindle-shaped virion structure are two proteins, VP1 as the major capsid protein, and VP3 as the minor capsid protein. The primary structure of VP1 consists of a proteolytic cleavage site at position 66 that is believed to be necessary for virus evolution. Recent studies showed that genetic mutation of the amino acid, glutamate (E) at position 66 in VP1 which …
Describing Shen & Shen Ming Via A Hybrid Quantum Computational Model, Alex M. Cullen, Johnny Lemau
Describing Shen & Shen Ming Via A Hybrid Quantum Computational Model, Alex M. Cullen, Johnny Lemau
Student Research Symposium
Definitions for Traditional Chinese Medicine (TCM) terminology within the context of quantum biology (QB) have recently been proposed. These definitions aim to elucidate concepts such as qi meridians in TCM. Our study presents a hypothesis that seeks to provide an operational definition for Spirit (Shen) and Bright Spirit (Shen Ming) in TCM via a scoping review. We propose that Shen represents physical, phenomenological proto-consciousness/consciousness in the forms of computation, such as singular particles/bits/qubits, computers, organisms, or computational strategies, whereas Shen Ming may refer to emergent, quasi-physical meta-proto-consciousness/consciousness formed by coherent relationships of multiple orchestrated/integrated units of computation; manifesting itself as …
Efficacy Of Curcumin In Asthma: A Systematic Review And Meta Analysis, Tabitha Grow, Adam Sadowski
Efficacy Of Curcumin In Asthma: A Systematic Review And Meta Analysis, Tabitha Grow, Adam Sadowski
McNair Symposium
Over 23 million people are affected by asthma in the United States and 262 million individuals globally. Asthma, if poorly controlled, is associated with significant morbidity as well as increased risk for mortality. Asthma involves several complex inflammatory pathways and processes including an increase in immune cell activation. Curcumin, the active constituent found in turmeric, has been studied in numerous in-vivo and in-vitro studies to generate anti-inflammatory effects in pulmonary diseases and, more recently, an increase in clinical data has become available. Since the most recent review assessing the role of curcumin in pulmonary disorders, additional clinical trials have been …
Amino-Terminal Sequencing Of Ssv1 Major Capsid Protein Vp1 Mutants, Nichole D. Procter, Kenneth M. Stedman, Ignacio De La Higuera, George Kasun, Ajay Sapre
Amino-Terminal Sequencing Of Ssv1 Major Capsid Protein Vp1 Mutants, Nichole D. Procter, Kenneth M. Stedman, Ignacio De La Higuera, George Kasun, Ajay Sapre
Student Research Symposium
Unique lemon-shaped viruses, the Fuselloviridae, or Sulfolobus Spindle-Shaped Viruses (SSVs) of hyperthermophilic archaea are characterized by both their unusual structure and extreme thermal tolerance. The most well characterized of the SSVs is SSV1. Wild-type SSV1 tolerates multiple mutations to its genome while still remaining infectious, making this virus ideal to study molecular processes in extreme environments. The major capsid protein, VP1 forms the unique structure of the virus and provides protection for the genome. The amino terminus of the VP1 protein purified from wild-type SSV1 is glutamate 66 (E66) indicating proteolytic cleavage. E66 is universally conserved in all SSVs. Interestingly, …