Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Effect Of Animal Facility Construction On Basal Hypothalamic-Pituitary-Adrenal And Renin-Aldosterone Activity In The Rat, Hershel Raff, Eric D. Bruder, William E. Cullinan, Dana R. Ziegler, Eric P. Cohen
Effect Of Animal Facility Construction On Basal Hypothalamic-Pituitary-Adrenal And Renin-Aldosterone Activity In The Rat, Hershel Raff, Eric D. Bruder, William E. Cullinan, Dana R. Ziegler, Eric P. Cohen
Biomedical Sciences Faculty Research and Publications
Nearby construction can cause subtle, but important activation of the hypothalamic-pituitary-adrenal axis in laboratory rats.
Although loud noise and intense vibration are known to alter the behavior and phenotype of laboratory animals, little is known about the effects of nearby construction. We studied the effect of a nearby construction project on the classic stress hormones ACTH, corticosterone, renin, and aldosterone in rats residing in a barrier animal facility before, for the first 3 months of a construction project, and at 1 month after all construction was completed. During some of the construction, noise and vibrations were not obvious to investigators …