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Biochemistry, Biophysics, and Structural Biology
The Texas Medical Center Library
Erythrocyte; Sphingosine 1-Phosphate; Sphingosine Kinase 1; Adenosine Signaling; Hypoxia Adaptation; Oxygen Release; Glucose Metabolism; Sickle Cell Disease
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Full-Text Articles in Medicine and Health Sciences
Role And Regulation Of Sphingosine 1-Phosphate In Erythrocyte, Kaiqi Sun
Role And Regulation Of Sphingosine 1-Phosphate In Erythrocyte, Kaiqi Sun
Dissertations & Theses (Open Access)
Sphingosine 1-phosphate (S1P) is a bioactive signaling sphingolipid produced in every mammalian cell. It plays a variety of important roles both in and outside of cells. S1P is highly enriched in mature erythrocytes because of the high enzymatic activity of the S1P-generating enzyme Sphingosine Kinase 1 (Sphk1) and the absence of S1P degrading enzymes. Erythrocytes are considered only a major reservoir for S1P because they supply S1P to the circulation for the regulation of various physiological processes which include but are not limited to immune cell trafficking, endothelial integrity and hematopoietic stem cell mobilization. However, if S1P plays a role …