Medicine and Health Sciences Commons^™

“Nothing But Blows”: Herman Melville And The Contagion Of Authority, Conrad Irving Brittenham

Senior Projects Spring 2016

In Chapter Thirty Six of Moby Dick, “The Quarter Deck,” captain Ahab rallies the Pequod’s crew behind his hunt for Moby Dick, met with no opposition other than from the ship's first mate, Starbuck. After heatedly bickering for some time, Ahab mentions in an aside, “Something shot from my dilated nostrils, he has inhaled it in his lungs. Starbuck now is mine; cannot oppose me now, without rebellion” (168). What follows is Starbuck’s “tacit acquiescence” to Ahab’s demands. Though it is unclear exactly what the “something” is that comes out of Ahab’s nose, it is clear that this one-track-mind captain …

Enhancing The Immune Response Through Ikkbeta-Induced Activation Of Nf-Kappab, Emily Hopewell

USF Tampa Graduate Theses and Dissertations

Nuclear factor-κB (NF-κB) is one of the main regulators of inflammatory and immune responses. It is a family of transcription factors composed of five members: RelA, RelB, cRel, NF-κB1 (p105/p50), and NF-κB2 (p100/p52). Homo- and hetero-dimers of family members are inhibited by inhibitor of &klappaB (IκB) family members and activated by IκB kinase (IKK) family members. The IKK family is comprised of IKKα, IKKΒ, and IKKγ. The focus of my dissertation delves into the role of NF-κB activation by IKKΒ in both an immunotherapy setting and its role in T cell mediated anti-tumor immune responses.

A central focus of immunotherapy …