Open Access. Powered by Scholars. Published by Universities.®
- Keyword
-
- Phototransduction (4)
- Diffusion (2)
- Finite volume scheme (2)
- Parabolic system (2)
- Parallel computation (2)
-
- Signaling (2)
- Computational fluid dynamics (1)
- DRBEM (1)
- Dark adapted rods (1)
- Hybrid Norwood (1)
- Hydrodynamic model (1)
- Hypoplastic left heart syndrome (1)
- Kinetics (1)
- Laser ablation (1)
- Light activation (1)
- Lumped parameter model (1)
- Lumped-Parameter Model (1)
- Meshless Method (1)
- Meshless Methods (1)
- Multi-scale CFD (1)
- Multiphase (1)
- Nanosecond laser ablation (1)
- Ode integration (1)
- Patient specific (1)
- Peer methods (1)
- Pharmacokinetics (1)
- Plasma (1)
- Reverse Blalock–Taussig shunt (1)
- Rod photoreceptors (1)
- Single-photon responses (1)
- Publication Type
Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury
A Meshless Approach To Computational Pharmacokinetics, Anthony Matthew Khoury
Doctoral Dissertations and Master's Theses
The meshless method is an incredibly powerful technique for solving a variety of problems with unparalleled accuracy and efficiency. The pharmacokinetic problem of transdermal drug delivery (TDDD) is one such topic and is of significant complexity. The locally collocated meshless method (LCMM) is developed in solution to this topic. First, the meshless method is formulated to model this transport phenomenon and is then validated against an analytical solution of a pharmacokinetic problem set, to demonstrate this accuracy and efficiency. The analytical solution provides a locus by which convergence behavior are evaluated, demonstrating the super convergence of the locally collocated meshless …
Patient-Specific Multiscale Computational Fluid Dynamics Assessment Of Embolization Rates In The Hybrid Norwood: Effects Of Size And Placement Of The Reverse Blalock–Taussig Shunt, Ray Prather, John Seligson, Marcus Ni, Eduardo Divo, Alain J. Kassab, William Decampli
Patient-Specific Multiscale Computational Fluid Dynamics Assessment Of Embolization Rates In The Hybrid Norwood: Effects Of Size And Placement Of The Reverse Blalock–Taussig Shunt, Ray Prather, John Seligson, Marcus Ni, Eduardo Divo, Alain J. Kassab, William Decampli
Publications
The hybrid Norwood operation is performed to treat hypoplastic left heart syndrome. Distal arch obstruction may compromise flow to the brain. In a variant of this procedure, a synthetic graft (reverse Blalock–Taussig shunt) is placed between the pulmonary trunk and innominate artery to improve upper torso blood flow. Thrombi originating in the graft may embolize to the brain. In this study, we used computational fluid dynamics and particle tracking to investigate the patterns of particle embolization as a function of the anatomic position of the reverse Blalock–Taussig shunt. The degree of distal arch obstruction and position of particle origin influence …
Multi-Scale Cardiovascular Flow Analysis By An Integrated Meshless-Lumped Parameter Model, Leonardo A. Bueno, Eduardo A. Divo, Alain J. Kassab
Multi-Scale Cardiovascular Flow Analysis By An Integrated Meshless-Lumped Parameter Model, Leonardo A. Bueno, Eduardo A. Divo, Alain J. Kassab
Publications
A computational tool that integrates a Radial basis function (RBF)-based Meshless solver with a Lumped Parameter model (LPM) is developed to analyze the multi-scale and multi-physics interaction between the cardiovascular flow hemodynamics, the cardiac function, and the peripheral circulation. The Meshless solver is based on localized RBF collocations at scattered data points which allows for automation of the model generation via CAD integration. The time-accurate incompressible flow hemodynamics are addressed via a pressure-velocity correction scheme where the ensuing Poisson equations are accurately and efficiently solved at each time step by a Dual-Reciprocity Boundary Element method (DRBEM) formulation that takes advantage …
Time-Stepping For Laser Ablation, Harihar Khanal, David Autrique, Vasilios Alexiades
Time-Stepping For Laser Ablation, Harihar Khanal, David Autrique, Vasilios Alexiades
Publications
Nanosecond laser ablation is a popular technique, applied in many areas of science and technology such as medicine, archaeology, chemistry, environmental and materials sciences. We outline a computational model for radiative and collisional processes occurring during ns-laser ablation, and compare the performance of various low and high order time-stepping algorithms.
Hydrodynamic Modeling Of Ns-Laser Ablation, David Autrique, Vasilios Alexiades, Harihar Khanal
Hydrodynamic Modeling Of Ns-Laser Ablation, David Autrique, Vasilios Alexiades, Harihar Khanal
Publications
Laser ablation is a versatile and widespread technique, applied in an increasing number of medical, industrial and analytical applications. A hydrodynamic multiphase model describing nanosecond-laser ablation (ns- LA) is outlined. The model accounts for target heating and mass removal mechanisms as well as plume expansion and plasma formation. A copper target is placed in an ambient environment consisting of helium and irradiated by a nanosecond-laser pulse. The effect of variable laser settings on the ablation process is explored in 1-D numerical simulations.
Models Of Phototransduction In Rod Photoreceptors, Harihar Khanal, Vasilios Alexiades
Models Of Phototransduction In Rod Photoreceptors, Harihar Khanal, Vasilios Alexiades
Publications
Phototransduction is the process by which photons of light generate an electrical response in retinal rod and cone photoreceptors, thereby initiating vision. We compare the electrical response in salamander rods from increasingly more (spacialy) detailed models of phototransduction: 0-dimensional (bulk), 1-dimensional (longitudinal), 2-dimensional (axisymmetric), and 3-dimensional (with incisures). We discuss issues of finding physical parameters for simulation and validation of models, and also present some computational experiments for rods with geometry of mouse and human photoreceptors.
Multiphoton Response Of Retinal Rod Photoreceptors, Vasilios Alexiades, Harihar Khanal
Multiphoton Response Of Retinal Rod Photoreceptors, Vasilios Alexiades, Harihar Khanal
Publications
Phototransduction is the process by which light is converted into an electrical response in retinal photoreceptors. Rod photoreceptors contain a stack of (about 1000) disc membranes packed with photopigment rhodopsin molecules, which absorb the photons. We present computational experiments which show the profound effect on the response of the distances (how many discs apart) photons happen to be absorbed at. This photon-distribution effect alone can account for much of the observed variability in response.
Response Of Dark-Adapted Retinal Rod Photoreceptors, H. Khanal, V. Alexiades, E. Dibenedetto
Response Of Dark-Adapted Retinal Rod Photoreceptors, H. Khanal, V. Alexiades, E. Dibenedetto
Publications
The process of phototransduction, whereby light is converted into an electrical response, in rod and cone photoreceptors in the retina, involves as a key setp, the diffusion of the cytoplasmic, signaling molecules cGMP (cyclic guanosime monophosphate) and Ca2+ diffuse in the cytoplasm (the fluid surrounding the discs). the complex geometry of the rod creates computational difficulties. We present spatio-temporal compuational models for interacctions and diffusion of cGMP and Ca2+ in the cytoplasm of vertebrate rod photoreceptors, as well as numerical simulations fo the response to light of dark-adapted Salamander rods.
Computational Models For Diffusion Of Second Messengers In Visual Transduction, Harihar Khanal
Computational Models For Diffusion Of Second Messengers In Visual Transduction, Harihar Khanal
Publications
The process of phototransduction, whereby light is converted into an electrical response in retinal rod and cone photoreceptors, involves, as a crucial step, the diffusion of cytoplasmic signaling molecules, termed second messengers. A barrier to mathematical and computational modeling is the complex geometry of the rod outer segment which contains about 1000 thin discs. Most current investigations on the subject assume a well-stirred bulk aqueous environment thereby avoiding such geometrical complexity. We present theoretical and computational spatio-temporal models for phototransduction in vertebrate rod photoreceptors, which are pointwise in nature and thus take into account the complex geometry of the …