Open Access. Powered by Scholars. Published by Universities.®
- Institution
- Keyword
-
- Loudness (2)
- Acoustic signal processing (1)
- Auditory Stimulus (1)
- Auditory system (1)
- Autonomic nervous system (1)
-
- Bioacoustics (1)
- Biological control systems (1)
- Brain (1)
- Calibration (1)
- Cells (1)
- Clinical (1)
- Diabetes (1)
- Dwarf sperm whale (1)
- Hearing (1)
- Histiocytosis (1)
- Histopathology (1)
- ION channels (1)
- Irrelevant Sound (1)
- Kogia (1)
- Luminance Level (1)
- MRI (1)
- Nervous system (1)
- PLCH (1)
- Perception (1)
- Polycystic Kidney Disease (1)
- Potassium channels (1)
- Prostate Cancer (1)
- Recalibration (1)
- Response Bias (1)
- SV40 (1)
Articles 1 - 9 of 9
Full-Text Articles in Medicine and Health Sciences
Immortalized Epithelial Cells From Human Autosomal Dominant Polycystic Kidney Cysts, Mahmoud Loghman-Adham, Surya M. Nauli, Carlos E. Soto, Barbara Kariuki, Jing Zhou
Immortalized Epithelial Cells From Human Autosomal Dominant Polycystic Kidney Cysts, Mahmoud Loghman-Adham, Surya M. Nauli, Carlos E. Soto, Barbara Kariuki, Jing Zhou
Pharmacy Faculty Articles and Research
Autosomal dominant polycystic kidney disease (ADPKD) is the result of mutations in one allele of the PKD1 or PKD2 genes, followed by "second hit" somatic mutations of the other allele in renal tubule cells. Continued proliferation of clonal cells originating from different nephron segments leads to cyst formation. In vitro studies of the mechanisms of cyst formation have been hampered by the scarcity of nephrectomy specimens and the limited life span of cyst-derived cells in primary culture. We describe the development of a series of immortalized epithelial cell lines from over 30 individual renal cysts obtained from 11 patients with …
Time Course Of Loudness Recalibration: Implications For Loudness Enhancement, Yoav Arieh, Lawrence E. Marks
Time Course Of Loudness Recalibration: Implications For Loudness Enhancement, Yoav Arieh, Lawrence E. Marks
Department of Psychology Faculty Scholarship and Creative Works
Loudness recalibration, the effect of a relatively loud 2500-Hz recalibrating tone on the loudness of a relatively soft 2500-Hz target tone, was measured as a function of the interstimulus interval (ISI) between them. The loudness of the target tone, assessed by a 500-Hz comparison tone, declined when the ISI equaled or exceeded about 200 ms and leveled off at an ISI of about 700 ms. Notably, the target tone’s loudness did not change significantly at very short ISIs (<150 ms). The latter result is incompatible with the literature reporting loudness enhancement in this time window but is compatible with the suggestion made by Scharf, Buus, and Nieder [J. Acoust. Soc. Am. 112, 807–810 (2002)] that early measurements of enhancement were contaminated by the influence of the recalibrating tone on the comparison …
Magnetic Resonance Images Of The Brain Of A Dwarf Sperm Whale (Kogia Simus), L. Marino, K. Sudheimer, D. A. Pabst, J. I. Johnson
Magnetic Resonance Images Of The Brain Of A Dwarf Sperm Whale (Kogia Simus), L. Marino, K. Sudheimer, D. A. Pabst, J. I. Johnson
Veterinary Science and Medicine Collection
Cetacean (dolphin, whale and porpoise) brains are among the least studied mammalian brains because of the difficulty of collecting and histologically preparing such relatively rare and large specimens. Among cetaceans, there exist relatively few studies of the brain of the dwarf sperm whale (Kogia simus). Magnetic resonance imaging (MRI) offers a means of observing the internal structure of the brain when traditional histological procedures are not practical. Therefore, MRI has become a critical tool in the study of the brain of cetaceans and other large species. This paper represents the first MRI-based anatomically labelled three-dimensional description of the dwarf sperm …
Recalibrating The Auditory System: A Speed–Accuracy Analysis Of Intensity Perception, Yoav Arieh, Lawrence E. Marks
Recalibrating The Auditory System: A Speed–Accuracy Analysis Of Intensity Perception, Yoav Arieh, Lawrence E. Marks
Department of Psychology Faculty Scholarship and Creative Works
Recalibration in loudness perception refers to an adaptation-like change in relative responsiveness to auditory signals of different sound frequencies. Listening to relatively weak tones at one frequency and stronger tones at another make the latter appear softer. The authors showed recalibration not only in magnitude estimates of loudness but also in simple response times (RTs) and choice RTs. RTs depend on the sound intensity and may serve as surrogates for loudness. Most important, the speeded classification paradigm also provided measures of errors. RTs and errors can serve jointly to distinguish changes in sensitivity from changes in response criterion. The changes …
Pulmonary Langerhans Cell Histiocytosis, Muhammad Irfan, Javed Hussain, Riaz Lakdawala, Fayyaz Hussain, Javaid Khan
Pulmonary Langerhans Cell Histiocytosis, Muhammad Irfan, Javed Hussain, Riaz Lakdawala, Fayyaz Hussain, Javaid Khan
Section of Pulmonary & Critical Care
No abstract provided.
Cross-Modal Enhancement Of Perceived Brightness: Sensory Interaction Versus Response Bias, Yoav Arieh, Lawrence E. Marks, Eric C. Odgaard
Cross-Modal Enhancement Of Perceived Brightness: Sensory Interaction Versus Response Bias, Yoav Arieh, Lawrence E. Marks, Eric C. Odgaard
Department of Psychology Faculty Scholarship and Creative Works
Stein, London, Wilkinson, and Price (1996) reported the presence of cross-modal enhancement of perceived visual intensity: Participants tended to rate weak lights as brighter when accompanied by a concurrent pulse of white noise than when presented alone. In the present study, two methods were used to determine whether the enhancement reflects an early-stage sensory process or a later-stage decisional process, such as a response bias. First, the enhancement was eliminated when the noise accompanied the light on only 25% versus 50% of the trials. Second, the enhancement was absent when tested with a paired-comparison method. These findings are consistent with …
Prostate Cancer: Some Clinical And Scientific Dilemmas., Paul D. Abel, El-Nasir Lalani
Prostate Cancer: Some Clinical And Scientific Dilemmas., Paul D. Abel, El-Nasir Lalani
Department of Pathology and Laboratory Medicine
No abstract provided.
Human Cytomegalovirus Chemokine Receptor Us28-Induced Smooth Muscle Cell Migration Is Mediated By Focal Adhesion Kinase And Src, Daniel N. Streblow, Jennifer Totonchy, Patsy Smith, Ryan Melnychuk, Laurel Hall, Dora Pancheva, Martine Smit, Paola Casarosa, David D. Schlaepfer, Jay A. Nelson
Human Cytomegalovirus Chemokine Receptor Us28-Induced Smooth Muscle Cell Migration Is Mediated By Focal Adhesion Kinase And Src, Daniel N. Streblow, Jennifer Totonchy, Patsy Smith, Ryan Melnychuk, Laurel Hall, Dora Pancheva, Martine Smit, Paola Casarosa, David D. Schlaepfer, Jay A. Nelson
Pharmacy Faculty Articles and Research
The human cytomegalovirus-encoded chemokine receptor US28 induces arterial smooth muscle cell (SMC) migration; however, the underlying mechanisms involved in this process are unclear. We have previously shown that US28-mediated SMC migration occurs by a ligand-dependent process that is sensitive to proteintyrosine kinase inhibitors. We demonstrate here that US28 signals through the non-receptor protein-tyrosine kinases Src and focal adhesion kinase (FAK) and that this activity is necessary for US28-mediated SMC migration. In the presence of RANTES (regulated on activation normal T cell expressed and secreted), US28 stimulates the production of a FAK Src kinase complex. Interestingly, Src co-immunoprecipitates with US28 in …
The Influence Of Slow Calcium-Activated Potassium Channels On Epileptiform Activity In A Neuronal Model Of Pyramidal Cells, Keun-Hang Susan Yang, Piotr J. Franaszczuk, Gregory K. Bergey
The Influence Of Slow Calcium-Activated Potassium Channels On Epileptiform Activity In A Neuronal Model Of Pyramidal Cells, Keun-Hang Susan Yang, Piotr J. Franaszczuk, Gregory K. Bergey
Mathematics, Physics, and Computer Science Faculty Articles and Research
An imbalance between excitation and inhibition can play an important role in the generation of epileptiform activity. Experimental evidence indicates that alterations of either synaptic activity or intrinsic membrane properties may contribute to this imbalance. The slow Ca2+ - activated K+ currents (sIAHP) limit neuronal firing rate and excitability and are therefore of great interest for their potential role in epileptogenesis. The sIAHP is found in both excitatory and inhibitory neurons, and its effect on these neurons can influence the network behavior. Simulations show that the increased excitability caused by reduction of inhibition by the sIAHP for inhibitory interneuron generates …