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Disruption Of Columnar And Laminar Cognitive Processing In Primate Prefrontal Cortex Following Cocaine Exposure, Ioan Opris, Greg A. Gerhardt, Robert E. Hampson, Sam A. Deadwyler

Neuroscience Faculty Publications

Prefrontal cortical activity in primate brain plays a critical role in cognitive processes involving working memory and the executive control of behavior. Groups of prefrontal cortical neurons within specified cortical layers along cortical minicolumns differentially generate inter- and intra-laminar firing to process relevant information for goal oriented behavior. However, it is not yet understood how cocaine modulates such differential firing in prefrontal cortical layers. Rhesus macaque nonhuman primates (NHPs) were trained in a visual delayed match-to-sample (DMS) task while the activity of prefrontal cortical neurons (areas 46, 8 and 6) was recorded simultaneously with a custom multielectrode array in cell …