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Articles 1 - 6 of 6
Full-Text Articles in Medicine and Health Sciences
The Clinical Value Of Oculomotor Assessments Across The Continuum Of Concussion, Dillon Richards
The Clinical Value Of Oculomotor Assessments Across The Continuum Of Concussion, Dillon Richards
Electronic Thesis and Dissertation Repository
Concussions are complex conditions that are difficult to manage medically. Variations in symptom presentation, intricate neurophysiological processes, and the availability of a variety of possible assessment tools may contribute to this complexity. Clinicians must use a broad approach, employing both subjective symptom assessment and objective assessments to confirm a diagnosis and/or monitor progression and recovery. Oculomotor function after concussion may be an important indicator of injury, given the interconnectedness of oculomotor function, vestibulo-ocular and visual systems, and even cognition. Oculomotor function may be assessed objectively or indirectly using patient-reported symptom checklists as part of subjective assessments. One way of objectively …
Role Of Decorin At The Fetal-Maternal Interface, Chidambra D. Halari
Role Of Decorin At The Fetal-Maternal Interface, Chidambra D. Halari
Electronic Thesis and Dissertation Repository
The human placenta is an invasive tumor-like structure, this invasion being physiological. A subset of placental trophoblast called extra-villous trophoblast invades the uterine decidua and remodels uterine arteries into low-resistance, high-flow tubes to permit adequate flow of maternal blood to nourish the fetus. A poor extra-villous trophoblast invasion and uterine arterial remodeling can lead to fetal growth restriction and a serious pregnancy-associated maternal disease preeclampsia. Decorin, a leucine-rich proteoglycan produced by uterine decidual cells restrains multiple trophoblast functions: self-renewal and differentiation of trophoblast stem cells, migration, invasion, proliferation and endovascular differentiation. Additionally, decidual overproduction of decorin was associated with preeclampsia, …
The Design And Evaluation Of A Subacromial Implant In Restoring Normal Glenohumeral Joint Stability In The Presence Of A Massive Irreparable Rotator Cuff Tear, Cole T. Fleet
Electronic Thesis and Dissertation Repository
Massive irreparable rotator cuff tears are a common cause of pain and disability. Several different treatment options are available for this pathology; however, these treatments have been associated with poor clinical outcomes when used to treat younger (<65 years), more active patients. The purpose of this thesis was to design and evaluate a subacromial implant in its ability to restore normal glenohumeral stability and range of motion. The implant was created as a modular device, which captured different implant thicknesses (5mm and 8mm) and constraints (high and low) within its design. In-vitro testing compared the ability of these implants to restore normal shoulder biomechanics. The results indicated the 5mm high constraint implant to be the most effective in restoring normal joint position. Furthermore, range of motion increased when the implant was paired with a tuberoplasty procedure. These results suggest this implant may be advantageous in treating younger patients.
Automation Through Deep-Learning To Quantify Ventilation Defects In Lungs From High-Resolution Isotropic Hyperpolarized 129xe Magnetic Resonance Imaging, Tuneesh Kaur Ranota
Automation Through Deep-Learning To Quantify Ventilation Defects In Lungs From High-Resolution Isotropic Hyperpolarized 129xe Magnetic Resonance Imaging, Tuneesh Kaur Ranota
Electronic Thesis and Dissertation Repository
Obstructive lung diseases are characterized by heterogenous ventilation. Hyperpolarized 129Xe gas lung magnetic resonance imaging (MRI) can examine lung ventilation heterogeneity by acquiring high-resolution isotropic images. The current gold standard of semi-automated (SA) segmentation can be used to quantify non-isotropic 129Xe lung images to generate ventilation defect percent (VDP), however, this method is not suitable for analysis of isotropic voxel 129Xe images due to the large number of slices. Therefore, we used a fully automated deep learning-based (DL) lung algorithm to calculate VDP from isotropic images. SNR, SA and DL-based VDP were calculated, showing a strong positive …
Role Of The Epithelial-To-Mesenchymal Transition (Emt) On Circulating Tumor Cell (Ctc) And Metastasis Biology In Prostate Cancer, Jenna M. Kitz
Role Of The Epithelial-To-Mesenchymal Transition (Emt) On Circulating Tumor Cell (Ctc) And Metastasis Biology In Prostate Cancer, Jenna M. Kitz
Electronic Thesis and Dissertation Repository
Prostate cancer is the second leading cause of cancer-related deaths in American men. Most of these deaths occur as the result of metastasis, which is associated with an epithelial-to-mesenchymal transition (EMT). EMT leads to greater migratory/invasive capacity and resistance to therapy. During metastasis and associated EMT, cancer cells shed from the primary tumor and disseminate throughout the body as circulating tumor cells (CTCs) in the bloodstream. CTCs have been correlated with increased metastatic disease, reduced survival, and therapy response/resistance. Assessing CTCs presents an opportunity to study cancer progression/treatment effectiveness from a blood test. However, outstanding questions regarding CTCs and EMT …
Connexin 43 Contributes To Phenotypic Variability Of The Mouse Skull, Elizabeth Jewlal
Connexin 43 Contributes To Phenotypic Variability Of The Mouse Skull, Elizabeth Jewlal
Electronic Thesis and Dissertation Repository
The purpose of this study was to determine whether connexin 43 (Cx43) contributes to craniofacial phenotypic variability. Skull shape and variation were compared within and among two heterozygous mutant mouse models (G60S/+ and I130T/+) that exhibit different levels of Cx43 channel function when compared to their wildtype counterparts (~80% and ~50% reduction in function, respectively). Results indicated mutants have significant differences in skull shape compared to wildtype littermates. Similar patterns of shape difference were found in both mutants. Increased skull shape variation and a disruption in the covariation of skull structures were observed in G60S/+ mutants only. These results show …