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Assessment Of Pseudo-Continuous Arterial Spin Labeling (Pcasl) Inter-Session Reliability In The Quantification Of Cerebral Perfusion, Mohammad Ahmad Awad
Assessment Of Pseudo-Continuous Arterial Spin Labeling (Pcasl) Inter-Session Reliability In The Quantification Of Cerebral Perfusion, Mohammad Ahmad Awad
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Arterial spin labeling (ASL) is a magnetic resonance imaging (MRI) technique used for measuring cerebral blood flow (CBF) in a completely non-ionizing and non invasive fashion. ASL is useful in perfusion studies on healthy adult & pediatric subjects, individuals who need multiple follow-ups, and patients with varying cerebrovascular diseases where changes in CBF can be used as an indicator of tissue viability. We used a variation of the ASL technique known as pseudo-continuous ASL (pCASL). This form of ASL is the clinical standard (Alsop et al., 2015). However, it is not well documented the that pCASL is reliable between sessions …
Effect Of Hybrid/Complex N-Glycosylation On Cardiac Voltage-Gated Ion Channel Expression, Austin R. Parrish
Effect Of Hybrid/Complex N-Glycosylation On Cardiac Voltage-Gated Ion Channel Expression, Austin R. Parrish
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Dilated cardiomyopathy (DCM) is one the most common forms of heart failure, with the majority of cases being idiopathic. Dr. Bennett’s laboratory previously showed that deletion of the Mgat1 gene in cardiomyocytes only (Mgat1KO) is sufficient to cause DCM leading to heart failure and early death. The Mgat1 gene product, GlcNAcT1, is responsible for initiating the formation of hybrid/complex N-glycosylation. These data suggest a link between abnormal glycosylation and heart disease; however, there is a mystery of how the specific changes in glycosylation contribute to heart disease etiology and progression. The proper function and gating of voltage-gated Na+ channels (Nav) …