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Articles 1 - 2 of 2
Full-Text Articles in Medicine and Health Sciences
The Long-Term Teratogenic Effect Of Prenatal Alcohol Exposure On The Somatosensory And Motor Cortex Of Rats, Tyson Chappell
The Long-Term Teratogenic Effect Of Prenatal Alcohol Exposure On The Somatosensory And Motor Cortex Of Rats, Tyson Chappell
Theses and Dissertations (ETD)
The primary goal of this dissertation was to examine the long-term effect of prenatal alcohol exposure (PAE) on the primary somatosensory (SI) and primary motor cortex (MI). For over 30 years, PAE has been shown to produce a triad of symptoms (growth deficits, craniofacial dysmorphologies and central nervous system disruptions) diagnosed as fetal alcohol syndrome (FAS) in children and adults. Since low to moderate levels of prenatal alcohol exposure are less likely to produce FAS symptoms in children, the term “PAE” in this dissertation typically refers to heavy/abusive/chronic levels of prenatal alcohol exposure (in humans this equates to 5+ drinks/per …
Probing The Role Of Nascent Helicity In Protein Function: P27kip1 As A Regulator Of The Cell Cycle, Steve Otieno
Probing The Role Of Nascent Helicity In Protein Function: P27kip1 As A Regulator Of The Cell Cycle, Steve Otieno
Theses and Dissertations (ETD)
p27kip1 binds to and regulates the activity of cyclin-dependent kinases (Cdks) which are the master timekeepers of the cell division cycle. Members of the p27 family of proteins, also including p21 and p57, are called cyclin-dependent kinase inhibitors (CKIs). The amino terminal domain of p27 inhibits Cdk activity and is referred to as the kinase inhibitory domain (KID). The KID is comprised of a cyclin-binding domain (D1) and a Cdk binding domain (D2) joined by a 22 residue linker domain (LH). Structural analysis of the KID in solution before binding its Cdk targets revealed that D1 and D2 are …