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Osteoinductivity Of Demineralized Bone: A Quantitative In Vitro Assessment, Yihong Zheng
Osteoinductivity Of Demineralized Bone: A Quantitative In Vitro Assessment, Yihong Zheng
Biological Sciences Theses & Dissertations
Acid demineralized bone (DMB) implanted in extraosseous sites induces bone formation. In vivo studies have shown that DMB stimulates the differentiation of mesenchymal cells into osteogenic cells. In this study an in vitro system was developed to demonstrate the osteoinductivity of DMB quantitatively. This in vitro working system was used to assess the osteoinductivity of variously processed DMB products as a means to evaluate their processing protocols. A human dermal fibroblastic (HDF) cell line was initiated from tissue explants as a working model, along with a human periosteal (HPO) cell line as a control. Ground DMB processed by LifeNet Transplant …