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- Keyword
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- <p>Aorta -- Aging.</p> <p>Acetaminophen -- Toxicology.</p> (1)
- <p>Body composition.</p> <p>Teenage boys -- Physiology.</p> <p>Skinfold thickness -- Measurement.</p> <p>Human body -- Composition.</p> <p>Teenagers -- Physiology.</p> (1)
- <p>Cockroaches -- Physiology. </p> <p>Cockroaches -- Neurophysiology.</p> (1)
- <p>Endothelial cells.</p> <p>Wound healing.</p> (1)
- <p>Glucuronides. </p> <p>Glucuronides -- Secretion.</p> (1)
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- <p>Glucuronides.</p> <p>Biological transport.</p> (1)
- <p>Kinematics.</p> <p>Dynamics, Rigid.</p> <p>Shoulder joint -- Physiology.</p> <p>Shoulder pain -- Treatment.</p> (1)
- <p>Melanoma.</p> (1)
- <p>Metastasis.</p> <p>Testicular -- Cancer.</p> <p>Proto-oncogene -- SKI.</p> <p>Bone morphogenetic proteins.</p> (1)
- <p>Nervous system – Diseases.</p> <p>Nervous system – Degeneration – Treatment.</p> <p>Nervous system – Degeneration – Surgery.</p> <p>Neural stem cells.</p> <p>Brain Stimulation.</p> <p>Parkinson’s disease – Treatment.</p> (1)
- <p>Nitric oxide synthase.</p> <p>Manganese enzymes.</p> <p>Superoxide dismutase.</p> (1)
- <p>Obesity -- Research.</p> <p>Hypertension -- Research.</p> <p>Animal models in research.</p> (1)
- <p>Soldiers -- Health and hygiene -- United States.</p> <p>Musculoskeletal system -- Wounds and injuries.</p> (1)
- <p>Veterans -- Diseases -- Appalachian Region.</p> <p>Veterans -- Health and hygiene -- Appalachian Region.</p> <p>Health promotion -- Appalachian Region.</p> (1)
- Acute chronic Workload (1)
- Aging; aorta; acetaminophen; ROS; cell signaling (1)
- Animal models (1)
- Bone morphogenetic protein (1)
- Borg's Scale (1)
- Deep brain stimulation (1)
- Fatigue (1)
- Injury Risk (1)
- Kinematics (1)
- Metastasis (1)
- Military Injuries (1)
- Neural stem cells (1)
- Neurodegeneration (1)
- Neuroregeneration (1)
- Nicotine (1)
- Nitric oxide (1)
Articles 1 - 15 of 15
Full-Text Articles in Medicine and Health Sciences
Current And Novel Neuroregenerative Therapies, Arrin Brooks
Current And Novel Neuroregenerative Therapies, Arrin Brooks
Theses, Dissertations and Capstones
Underlying the physical and cognitive deficits consequent of many neuropathologies is one common factor, the loss of neurons. While neurodegenerative diseases, stroke, and traumatic brain injury arise from a variety of etiologies, they all ultimately result in injury and/or death of neuronal cells and concomitant functional deficits. In the present work we primarily focus on current and potential treatments for localized lesions, particularly those in the striatum of Parkinson’s disease (PD) or the cortex as in stroke. First, we discuss a new surgical technique for deep brain stimulator (DBS) placement, as DBS is a mainstay treatment for movement disorders including …
The Effect Of Serratus Anterior Fatigue On Scapular Kinematics, Nathan Curtis Harrison
The Effect Of Serratus Anterior Fatigue On Scapular Kinematics, Nathan Curtis Harrison
Theses, Dissertations and Capstones
Background: Shoulder pain is a common occurrence in the general population. Pain has been associated with shoulder impairments and pathology. Associations between shoulder limitations, impairments, and mechanisms of injury and altered scapular motion appear in the literature. Fatigue of the scapular stabilizing muscles resulting from repeated arm motion has been reported to alter scapular kinematics, which could result in shoulder pathology, especially impingement.
Purpose: The purpose of this study was to examine the effects of fatigue of the serratus anterior muscle on scapular kinematics. The hypotheses were that there would be decreased posterior tilt and decreased upward rotation during arm …
Perceived Exertion And The Increase In Risk Of Injury In Rotc Cadets, Courtney D. Chiaramonte
Perceived Exertion And The Increase In Risk Of Injury In Rotc Cadets, Courtney D. Chiaramonte
Theses, Dissertations and Capstones
Context: Musculoskeletal injury in military personnel creates problems due to economic losses, and decreased training. The repetitive motions associated with military training and the daily physical training sessions can lead to the development of fatigue. Fatigue has been shown to contribute to 18% - 26% of musculoskeletal injuries. [7] Several studies have explored fatigue as a risk of injury during occupation. Fatigue has been shown to increase the perceived effort during physical exercise. The purpose of this study was to characterize the perception of effort during physical training sessions and injury rates in ROTC cadets throughout an academic year.
Methods …
Control Of Myosin Motor Activity And Actin Filament Translation By Alteration Of Assay Reducing Potential, Siva Krishna Nalabotu
Control Of Myosin Motor Activity And Actin Filament Translation By Alteration Of Assay Reducing Potential, Siva Krishna Nalabotu
Theses, Dissertations and Capstones
The use of biomolecular motors for nanotechnological applications has been impaired by an inability to control biomolecular motor activity in a temporal fashion. Previous data has suggested that myosin activity can be modulated by inducing changes in the degree of myosin oxidation. The hypothesis of this study is that myosin motor activity can be regulated by altering the amount of antioxidants and reducing agents present in assay solution. To test this hypothesis we systematically altered the concentration of reducing agents and examined the effects of these changes on myosin-dependent actin filament translation. Our findings indicate that myosin activity can be …
Loss Of Ski Expression In Testicular Cancer Leads To An Enhanced Invasive Phenotype Through Both Bmp-Dependent And Bmp-Independent Pathways, Amy N. Nash
Theses, Dissertations and Capstones
The proto-oncogene SKI is a transcription factor and a co-repressor of the TGFβ superfamily, including TGF
β and BMP. However, additional data suggests that SKI may function as a tumor suppressor in some cell types. The TGFβ superfamily has been implicated in cancer progression and germ cell migration. Testicular cancer afflicts men during their peak reproductive years and is the most common cancer among men of this age group. Cisplatin-based chemotherapy is the standard treatment for testicular cancer. This treatment can lead to undesirable side effects, including infertility. We have shown that SKI expression is decreased in testicular germ cell …
Enumeration Of Endothelial Progenitor Cells In Hind Limb Suspended Rats And The Mechanics Of Endothelial Wound Healing, Jarrod Matthew Pennington
Enumeration Of Endothelial Progenitor Cells In Hind Limb Suspended Rats And The Mechanics Of Endothelial Wound Healing, Jarrod Matthew Pennington
Theses, Dissertations and Capstones
The endothelium repairs itself through two methods. One is by the activity of circulating endothelial progenitor cells (EPCs). EPCs are immature endothelial cells that circulate the bloodstream that are capable of proliferation and differentiation into mature endothelium. It is thought that EPCs contribute to the repair and replacement of damaged endothelial cells in the process of reendothelialization. Physical inactivity and bed rest are known to be deleterious to the endothelium. It is possible that this inactivity is also deleterious to the number of viable EPCs, which would reduce the ability of the endothelium to repair itself. We used hind limb …
Chronic Acetaminophen Treatment Influences Indices Of Reactive Oxygen Species Accumulation In The Aging Fisher 344 X Brown Norway Rat Aorta, Sarath Meduru
Theses, Dissertations and Capstones
We have previously reported that aging in the Fisher 344 X Brown Norway (FBN) rat aorta is characterized by increased levels of ROS and alterations in cell signaling. Acetaminophen was found to scavenge free radicals in recent ischemia-reperfusion studies. Here we examined if chronic treatment with a therapeutic dose of acetaminophen attenuates age-associated increase in aortic ROS accumulation and signaling. FBN rats (27 month old; n=8) were subjected to 6 months of treatment with a therapeutic dose of acetaminophen (30mg/kg/day), with age-matched untreated FBN rats as controls. Protein oxidation levels were altered in control and treated aortae compared to aortae …
The Expression And Function Of Ppar And Hif-1 In Human Melanoma, Caroline Mills
The Expression And Function Of Ppar And Hif-1 In Human Melanoma, Caroline Mills
Theses, Dissertations and Capstones
The first part of my dissertation focuses on the expression and function of PPARs in human melanoma. I found that the A375 cells were significantly growth inhibited in response to PGJ2 and troglitazone treatment. HEMn-LP showed significant growth inhibition in response to troglitazone. I found that PPARγ and PPARδ mRNA is present in both the SK-Mel 28 and A375 cells. The relative level of PPARα mRNA expression is highest in SK-Mel 28 cells, ~3 fold higher relative to both the normal human melanocytes and A375 cells. PPARγ protein was ~50% higher in both SK-Mel 28 and A375 cells relative to …
The Zucker Rat As A Model Of Obesity-Hypertension, Ryan Morrison
The Zucker Rat As A Model Of Obesity-Hypertension, Ryan Morrison
Theses, Dissertations and Capstones
Hypertension is a serious health problem that affects approximately 1 in 4 American adults. Most cases are diagnosed as essential hypertension, meaning that the exact cause is unknown. In most patients, however, excess weight is a major contributory factor to the development of essential hypertension. The role of obesity in promoting hypertension is now well documented and has become the foundation for an entire field of research known alternately as obesity-hypertension, obesity-induced hypertension, or obesity-associated hypertension. In this field, rapid advances are being made in our understanding of how obesity and hypertension are linked. A plethora of related risk factors, …
Discovering The Barriers To Health-Promoting Lifestyles Among Appalachian Veterans With Uncontrolled Hypertension, Tara L. Porter
Discovering The Barriers To Health-Promoting Lifestyles Among Appalachian Veterans With Uncontrolled Hypertension, Tara L. Porter
Theses, Dissertations and Capstones
Introduction: The purpose of this study was to discover the barriers to health promoting lifestyles among the Appalachian veteran population with uncontrolled hypertension.
Design: A quantitative research study was conducted over five months using a non-experimental, descriptive research design. Pender’s Health Promotion Model served as the study’s framework. Subjects were recruited from a primary care setting through advertisement within the hospital. A convenience sample of thirty-two subjects was obtained.
Method: The Health Promotion Lifestyle Profile (HPLP) II survey assessed for barriers to controlled hypertension in the following areas: health-promoting lifestyle, health responsibility, stress management, spiritual growth, interpersonal relationships, nutrition, and …
Renal Basolateral Transport Of Glucuronides And Other Organic Anions In Rat In Vitro Models, Sarah L. Miles
Renal Basolateral Transport Of Glucuronides And Other Organic Anions In Rat In Vitro Models, Sarah L. Miles
Theses, Dissertations and Capstones
Glucuronidation is a common Phase II biotransformation reaction that increases the hydrophilicity, and thus elimination, of toxins, xenobiotics, and endogenous compounds. Previous studies suggest that the kidney can secrete glucuronide conjugates, but the renal transport mechanisms for glucuronide secretion have not been determined. Based on the chemical nature of glucuronide metabolites, it is hypothesized that organic anion transporter (OAT) proteins along the basolateral membrane of the renal proximal tubule promote renal accumulation of glucuronide conjugates. The purpose of this study was to develop a rat renal proximal tubule model which demonstrates OAT activity and by which the contribution of OAT …
Hk-2 Cells As A Human Model Of Glucuronide Transport, Eliza E. Robertson
Hk-2 Cells As A Human Model Of Glucuronide Transport, Eliza E. Robertson
Theses, Dissertations and Capstones
Glucuronidation is primarily a pathway of detoxification in most species, but many glucuronide conjugates are associated with toxicity. Numerous drugs are excreted in the urine as glucuronide conjugates. Being organic anions, it is likely that glucuronides are secreted into the urine by organic anion transporters found in renal proximal tubule cells (PTCs). Some drugs that are metabolized by glucuronidation have been shown to cause renal toxicity, yet little is known about the renal handling of glucuronide conjugates. It is hypothesized that glucuronides are transported into renal PTCs by an organic anion transporter (OAT) on the basolateral membrane of the cell. …
Detection Of Forces And Body Load In Standing And Walking In The American Cockroach, J. Adam Noah
Detection Of Forces And Body Load In Standing And Walking In The American Cockroach, J. Adam Noah
Theses, Dissertations and Capstones
Sense organs in the legs that detect body weight are an important component in the regulation of posture and locomotion. This thesis seeks to gain an understanding of how body weight is detected by sense organs of the legs, and determine how this information influences muscle activities in standing and walking. The first study tested the ability of tibial campaniform sensilla (receptors that monitor forces in the cockroach leg) to encode variations in body load using magnets attached to the thorax. Recordings of sensory activities in freely standing animals showed that proximal tibial sensilla (oriented perpendicular to the leg long …
Comparison Of Hydrostatic Weighing And Plethysmography Techniques For The Development Of Skinfold Prediction Equations For Children, Tomoko Tozuka
Comparison Of Hydrostatic Weighing And Plethysmography Techniques For The Development Of Skinfold Prediction Equations For Children, Tomoko Tozuka
Theses, Dissertations and Capstones
Regression equations between skinfold (SKF) measurements and air displacement plethysmography (ADP) were determined 6 to 18 year old athletes (80 males / 34 females) using Pearson r correlation coefficients. Triceps and mid-calf SKF and percent body fat (%BF) by ADP were measured during an Athletic Ability Assessment at The HIT Center (Huntington, WV). A high relationship was found between SKF and %BF by ADP (males; r2 = .76, females; r2 = .74, all; r2 = .77). Data from the subjects were compared with similar correlations determined between SKF and %BF by hydrostatic weighing (HW) from another study …
The Regulation Of Manganese Superoxide Dismutase And Inducible Nitric Oxide Synthase By Nuclear Factor-Kappa B And Activator Protein 1 In Rat Aortic Endothelial Cells, Scott L. Cobbs
Theses, Dissertations and Capstones
Inducible nitric oxide synthase (iNOS) and manganese superoxide dismutase (MnSOD) are two enzymes that influence reactive oxygen species within the cell. The promoter regions for the genes encoding these enzymes have two specific transcription factor elements in common, activator protein 1 (AP-1) and nuclear factor kappa b (NF-KB). This study was initiated to determine if either NF-KB or AP-1 regulates the transcription of both genes in endothelial cells. To test whether NF-KB or AP-1 binding sites in the MnSOD and iNOS promoter region were important for transcriptional regulation, we performed induction analysis using various deletion constructs of MnSOD and iNOS …