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Articles 1 - 15 of 15
Full-Text Articles in Medicine and Health Sciences
Computational Investigation Of The Interactions Between Bioactive Compounds And Biological Assemblies, Tye D. Martin
Computational Investigation Of The Interactions Between Bioactive Compounds And Biological Assemblies, Tye D. Martin
Shared Knowledge Conference
Design of small molecules is an ongoing focus for developing agents against pathogenic viruses and bacteria that are threats to worldwide health. Viruses such as Zika feature assemblies of repeat peptide subunits or capsid proteins which are potential targets for antiviral compounds. Other protein assemblies are implicated in pathology of Alzheimer’s Disease (AD) and additional neurodegenerative diseases characterized by large assemblies of misfolded proteins such as amyloid-beta (Aβ) and tau. Recent studies on a class of conjugated polyelectrolytes (CPEs) with phenylene ethynylene moieties and charged functional groups have shown potential both as bioactive antimicrobials and theragnostic sensing agents for tracking …
How Concussions Alter Brain Network Properties: Towards Better Diagnoses Of Concussions, Sara Krehbiel, Joanna R. Wares
How Concussions Alter Brain Network Properties: Towards Better Diagnoses Of Concussions, Sara Krehbiel, Joanna R. Wares
Annual Symposium on Biomathematics and Ecology Education and Research
No abstract provided.
Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala
Cost-Effective Paper-Based Diagnostic Using Split Proteins To Detect Yeast Infections, Zachary R. Berglund, Kevin V. Solomon, Mohit S. Verma, Moiz Rasheed, Zachary Hartley, Kevin Fitzgerald, Kok Zhi Lee, Janice Chan, Julianne Dejoie, Makayla Schacht, Alex Zavala
The Summer Undergraduate Research Fellowship (SURF) Symposium
The common yeast infection, vulvovaginal candidiasis, affects three out of four women throughout their lifetime and can be spread to their child in the form of oral candidiasis (thrush). This disease is caused by the fungal pathogen Candida albicans, which is also a major cause of systemic candidiasis, a rarer but deadly disease with up to a 49% lethality rate. Current widely-used diagnostic methods include cell cultures, pH tests, and antibody detection, to assist effective treatment. Despite availability of various diagnostic methods, there is no inexpensive, rapid, and accurate way to detect C. albicans infection. This project aims to …
Tissue Clearing As A Mechanism To Identify Changes In Fibronectin Structure During Breast Cancer Metastasis, Maryam Nuru, Kelsey Hopkins, Luis Solorio
Tissue Clearing As A Mechanism To Identify Changes In Fibronectin Structure During Breast Cancer Metastasis, Maryam Nuru, Kelsey Hopkins, Luis Solorio
The Summer Undergraduate Research Fellowship (SURF) Symposium
With metastasis accounting for approximately 90% of breast cancer deaths and an alarming number of over 300,000 new breast cancer cases to be diagnosed by the end of 2018, there is growing need to understand the process of breast cancer. Changes in the extracellular matrix (ECM) of the tumor microenvironment play an essential role in this deadly tumor progression. Specifically, the glycoprotein fibronectin (FN), has been identified to be up-regulated in patients with worse clinical outcomes. During tumor progression fibronectin undergoes conformational changes that aid in metastatic dissemination. In order to analyze the dynamic changes in FN expression and evaluate …
Classification Of Intensity-Modulated Proton Therapy Plans, Alice Liu
Classification Of Intensity-Modulated Proton Therapy Plans, Alice Liu
The International Student Science Fair 2018
Abstract
Title: Classification of IMPT Plans
Purpose:
Create a method to aid physicists and dosimetrists in the classification of Intensity Modulated Proton Therapy treatment plans.
Method:
A Python program was developed to read structure sets and dose grids from radiation treatment plans. The program outputs field-specific histograms of the number of voxels within the planning target volume that received dose and normalizes each histogram to the percent volume of the target that received each field’s contribution of the total dose. It then determines the number of Gaussian distributions in each histogram, which serves as an initial classification metric, and calculates …
El Impacto De Las Artes Visuales En Personas Afectadas Por Cáncer, Bettina Ingham
El Impacto De Las Artes Visuales En Personas Afectadas Por Cáncer, Bettina Ingham
ICOT 18 - International Conference on Thinking - Cultivating Mindsets for Global Citizens
El impacto de las artes visuales en el bienestar y la mejora de la calidad de vida de personas afectadas por cáncer.
Un programa diseñado para poner en práctica e investigar el alcance que tienen las artes visuales y el método de Estrategias de Pensamiento Visual para el desarrollo de habilidades de pensamiento que promueven la identificación y expresión verbal de las emociones, minimizando, en el caso de las personas convalecientes, el sufrimiento que va desde el dolor de la enfermedad hasta el miedo a la muerte.
Los efectos que la contemplación (percepción estética), el análisis y la práctica(proceso creativo) …
Structure Determination Of A Bioengineered Human/Porcine Factor Viii For Hemophilia A Treatment, And Improvements To The Human Factor Viii Model, Ian Smith
Graduate Student Symposium
Blood coagulation factor VIII (FVIII), is a non-enzymatic cofactor which plays a crucial role in the formation of a stable blood clot. Absence or deficiency of FVIII results in the blood disorder hemophilia A; with symptoms including internal hemorrhaging and the inability to stop bleeding from open wounds. Treatment of hemophilia A relies on infusions of blood, plasma, or protein concentrates to replace FVIII. Unfortunately, approximately 30% of patients receiving replacement FVIII generate pathologic anti-FVIII inhibitory antibodies, which both reduce the effectiveness of the FVIII therapeutic and increase the severity of hemophilia A symptoms.
We have determined the molecular structure …
Dexmedetomidine (Precedex) Induced Fever, Patrick Dealmeida Do, Michael Matrale Do
Dexmedetomidine (Precedex) Induced Fever, Patrick Dealmeida Do, Michael Matrale Do
Rowan-Virtua Research Day
Precedex is an intravenous, α-2 receptor agonist broadly used for analgesia, maintenance of sedation, and alcohol withdrawal treatment in the intensive care unit (ICU).
The most commonly reported adverse effects associated with precedex are hypotension and bradycardia1.
Fever has been reported with a 5-7% incidence rate. Our case shows a very impressive pyrexia in a 49 year old patient most likely associated to Precedex. When compared to the previously three reported cases his fever reached the largest value (T= 107ºF).
As its use becomes more and more common in the ICU, clinicians should be aware of this adverse effect especially …
A Case Of Signet Ring Cell Colon Carcinoma Initially Presenting As Acute Diverticulitis, Justin Derosa Do, Jonathan Foster Do, Drew Chiesa Do, Darshan Roy Md
A Case Of Signet Ring Cell Colon Carcinoma Initially Presenting As Acute Diverticulitis, Justin Derosa Do, Jonathan Foster Do, Drew Chiesa Do, Darshan Roy Md
Rowan-Virtua Research Day
This is a unique case of a female with an acute bout of diverticulitis who six weeks later on follow up colonoscopy, was found to have signet ring cell colon carcinoma. The purpose is to deliver awareness of this rare type of colon malignancy, emphasize the continued need for screening colonoscopy, and to provide the reader with a distinct and thought provoking spin on the conventional diagnosis of diverticulitis.
Refrigerated Stability Of Diluted Cisatracurium, Rocuronium, And Vecuronium For Skin Testing After Perioperative Anaphylaxis, Kristen Dinsmore, Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy Brown Phd, Alexei Gonzalez-Estrada Md
Refrigerated Stability Of Diluted Cisatracurium, Rocuronium, And Vecuronium For Skin Testing After Perioperative Anaphylaxis, Kristen Dinsmore, Bethany Campbell, Timothy Archibald, Greg Mosier, Stacy Brown Phd, Alexei Gonzalez-Estrada Md
Appalachian Student Research Forum
Rationale: The purpose of this study is to investigate the stored stability of dilutions of neuromuscular blocking agents (NMBAs), namely cisatracurium, rocuronium, and vecuronium, for skin prick/intradermal testing.
Methods: Concentrations of NMBAs were monitored by liquid chromatography-mass spectrometry (LC-MS/MS) for a period of 14 days. Dilutions of NMBAs were prepared in saline by factors of 10x, 100x, 1,000x, 10,000x, and 100,000x as sensitivity of the assay allowed. Diluted drug products were stored in a laboratory refrigerator until sampling. On sampling days, aliquots of each dilution were removed and compared to a freshly prepared set of reference dilutions.
Results: The results …
Lumbar Decompression Surgery: Does Chronic Steroid Use Increase The Risk Of Postoperative Infectious Complications? – A Study Of The National Surgical Quality Improvement Program (Nsqip) Database, Shane Sobrio, Mikel Thista, Raj Rao, Alex Gu, Chapman Wei, Warren Yu
Lumbar Decompression Surgery: Does Chronic Steroid Use Increase The Risk Of Postoperative Infectious Complications? – A Study Of The National Surgical Quality Improvement Program (Nsqip) Database, Shane Sobrio, Mikel Thista, Raj Rao, Alex Gu, Chapman Wei, Warren Yu
GW Research Days 2016 - 2020
Intro: It has long been established that corticosteroids have a negative impact on the human immune system’s ability to function at an optimal level. Many past studies have shown that patient’s will have higher rates of infection if they are taking chronic steroids. What has yet to be established is just how much of an increased risk patients on chronic steroids have for infection after undergoing lumbar decompression surgeries, of which there are thousands per year. We hypothesize that patients on chronic steroids will have higher rates of surgical site infections and higher rates of other infections (UTI, pneumonia, etc.) …
Use Of Excel Spreadsheet Calculators In Handling Data Generated From Uv- Spectrometer, Mercy Okezue, Kari Clase, Steve Byrn
Use Of Excel Spreadsheet Calculators In Handling Data Generated From Uv- Spectrometer, Mercy Okezue, Kari Clase, Steve Byrn
BIRS Symposium
To ease the complexities of handling data generated from different analytical procedures, validated excel spreadsheet containing relevant formulas are developed to ensure the process of data handling will consistently produce the expected results. This paper introduces the use of Excel spreadsheets in handling data generated from using a UV-Spectrometer in determination of analyte concentration in various dosage forms
Instituting Process Control Mechanisms In A Quality Control Analytical Chemistry Laboratory, Mercy Okezue, Kari Lynn Clase, Stephen Byrn
Instituting Process Control Mechanisms In A Quality Control Analytical Chemistry Laboratory, Mercy Okezue, Kari Lynn Clase, Stephen Byrn
BIRS Symposium
Statistical Process Control by means of using control charts was a means of monitoring performance of analytical equipment. Quality control checks on test items using these equipment generated data used for plotting X-bar charts. The charts generated had warning and control limits which helped monitor system performance
Cam Impingement In A Collegiate Male Soccer Player With Bilateral Arthroscopic Labral Repair, Nayun Ahn
Cam Impingement In A Collegiate Male Soccer Player With Bilateral Arthroscopic Labral Repair, Nayun Ahn
UNO Student Research and Creative Activity Fair
Cam impingement in a collegiate male soccer player with the bilateral arthroscopic labral repair.
To demonstrate cam impingement and recurrent cam deformity caused by femoroacetabular impingement after bilateral arthroscopic labral repair in a collegiate male soccer player. Cam impingement is caused by deformities of the femoral head. The deformity is generated due to overuse and high shear stress on the femoral head leading to restricted hip ROM by grinding the articular cartilage. It is typically detected in young, active male populations playing high-impact sports. In this case, one NCAA Division 1 soccer midfielder reported the recurrent cam impingement after he …
A Delayed Diagnosis Of Tarsometatarsal Ligament (Lisfranc) Sprain In A Female College Soccer Athlete And Foot Rehabilitation, Boyoung Park
A Delayed Diagnosis Of Tarsometatarsal Ligament (Lisfranc) Sprain In A Female College Soccer Athlete And Foot Rehabilitation, Boyoung Park
UNO Student Research and Creative Activity Fair
A Delayed Diagnosis of Tarsometatarsal Ligament (Lisfranc) Sprain in a Female College Soccer Athlete and Foot Rehabilitation
Park B*, Nicola M*, Wilkins S*: *University of Nebraska at Omaha, Omaha, NE
Objective: To emphasize the importance of the correct treatment protocol and the proper rehabilitation exercises based on the patient’s injury condition and healing process. Background: A 22-year-old female division I soccer athlete underwent tarsometatarsal ligament repair to stabilize midfoot. The patient started feeling pain in the dorsal aspect of her left 1st and 2nd metatarsals at the beginning of the season, however, she reported no specific mechanism of injury …