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Full-Text Articles in Medicine and Health Sciences
Design And Validation Of Eco-Friendly Chemometric-Assisted Spectrophotometric Methods For The Simultaneous Determination Of Chlorzoxazone, Paracetamol, And Aceclofenac In The Presence Of Their Main Impurities, Ayoub N. Mozayad, Marwa A. Fouad, Ehab F. Elkady
Design And Validation Of Eco-Friendly Chemometric-Assisted Spectrophotometric Methods For The Simultaneous Determination Of Chlorzoxazone, Paracetamol, And Aceclofenac In The Presence Of Their Main Impurities, Ayoub N. Mozayad, Marwa A. Fouad, Ehab F. Elkady
Bulletin of Faculty of Pharmacy Cairo University
Objective: The goal of this work is to develop and validate eco-friendly spectrophotometric methods for the simultaneous determination of chlorzoxazone (CHZ), paracetamol (PAR), and aceclofenac (ACF) in the presence of their major impurities, specifically 2-amino-4-chlorophenol (ACP), 4-aminophenol (4-AP), and diclofenac (DCF), in commercially available tablet dosage forms using chemometric techniques. Method: Six chemometric models, namely classical least squares (CLS), partial least squares (PLS) regression, and principal component regression (PCR), in addition to feed-forward back-propagation artificial neural networks (FFBP-ANN), cascade-forward back-propagation artificial neural networks (CFBP-ANN), and radial basis function artificial neural networks (RBF-ANN), were employed to analyze the synthetic mixtures, which …