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E2f Transcription Factor 1 And Its Role In The Cell Cycle And Tumor Suppressor Proteins, Thea Hisuler, Yu Kuang

AANAPISI Poster Presentations

E2F Transcription Factor 1 (E2F1) E2F1 is a transcription factor, in which its expression is increased in human cancers. “Transcription factor E2F1 binds to and activates transcription,” in return leading to increased transcription at the G1 and S phase of the cell cycle (Slansky). The E2F transcription factor family “plays a crucial role in the control of cell cycle and action of tumor suppressor proteins and is also a target of the transforming proteins of small DNA tumor viruses” (NCBI).