Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 1 of 1
Full-Text Articles in Medicine and Health Sciences
Regulation Of Cancer Stem Cells: Lysine Methylation Of P53, William Holliday, Yu Kuang
Regulation Of Cancer Stem Cells: Lysine Methylation Of P53, William Holliday, Yu Kuang
AANAPISI Poster Presentations
The highly studied p53 protein regulates multiple transitions through the cell cycle effectively halting the growth of tumorlike masses.[1] This gene was primitively identified an oncogene; however, it was later derived that p53 functions as a tumor suppressor.[1] Named due to its mass in kDa, p53 is a phosphoprotein comprised of 393 amino acids.[1] Normal cells contain controlled, small quantities of p53 in order to facilitate the regulation of normal cell activities such as growth arrest, senescence,DNArepair, and apoptosis.[1,2] These features are pivotal the continuation of healthy cell production. Constructively, the functions of p53 work together to pause the cell …