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Analytical, Diagnostic and Therapeutic Techniques and Equipment
Enzyme-linked immunosorbent assay | Glycoproteins | CD antigens | Serum -- Analysis
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Development Of An Elisa Method For The Measurement Of Cd44 Expression In Human Serum, Ciara Hurley
Development Of An Elisa Method For The Measurement Of Cd44 Expression In Human Serum, Ciara Hurley
Theses
CD44 is a cell surface glycoprotein (mol. wt. =85-95 kDa) which has been implicated in lymphocyte-HEV interactions and the process of lymphocyte homing. CD44 is a complex glycoprotein which undergoes extensive alternative splicing to generate various CD44 isoforms. CD44 functions include the delivery of an activation signal to T-cells, binding to hyaluronate, mediation of lymphocyte homing, and the spread of metastatic cells. CD44 has been particularly implicated in the dissemination of non- Hodgkin's lymphoma and as such may serve as a useful prognostic marker of disease progression. CD44 measurement in serum may provide a rapid, inexpensive and relatively non-invasive prognostic …