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Full-Text Articles in Medicine and Health Sciences
The Mechanism Of Suppression By A Protective Peptide In A Mouse Model Of Multiple Sclerosis, Alaa Mansour Almatrook
The Mechanism Of Suppression By A Protective Peptide In A Mouse Model Of Multiple Sclerosis, Alaa Mansour Almatrook
Theses and Dissertations
Multiple Sclerosis (MS) is an autoimmune demyelinating disease of the central nervous system (CNS). MS is characterized by an immune response directed against myelin sheath. This immune response results in demyelination, which leads to the clinical symptoms of MS. It is accepted that MS is mediated by T helper 1/ T helper 17 immune responses. However, the role of B cells and antibodies (Abs) are still under debate. The primary animal model for MS is the experimental autoimmune encephalomyelitis (EAE) that is induced by immunizing animals with one of the myelin components. We previously showed that immunizing mice with the …
Amelioration Of Experimental Autoimmune Encephalomyelitis Using The Myelin Oligodendrocyte Glycoprotein35-85 Peptide, Vrushali Vinay Agashe
Amelioration Of Experimental Autoimmune Encephalomyelitis Using The Myelin Oligodendrocyte Glycoprotein35-85 Peptide, Vrushali Vinay Agashe
Theses and Dissertations
Multiple sclerosis (MS) is a chronic debilitating disease affecting the central nervous system (CNS) in humans. Experimental autoimmune encephalomyelitis (EAE) remains the primary animal model of MS. MS/EAE are considered to be autoimmune diseases mediated by CD4+ T helper (TH) cells. The role of B cells and antibody is under debate. Previous studies established B cell dependent (induced with recombinant myelin oligodendrocyte glycoprotein, [rMOG]) and B cell independent (induced with the MOG35-55 peptide) animal models of EAE. The identification of a unique B cell epitope (MOG amino acids [aa] 46-85) preceding the identified protective epitope (MOG61-85) led to the hypothesis …