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Full-Text Articles in Life Sciences
Expression And Role Of Gonadotropin-Releasing Hormone 2 And Its Receptor In Mammals, Amy Desaulniers, Rebecca A. Cederberg, Clay A. Lents, Brett R. White
Expression And Role Of Gonadotropin-Releasing Hormone 2 And Its Receptor In Mammals, Amy Desaulniers, Rebecca A. Cederberg, Clay A. Lents, Brett R. White
Department of Animal Science: Faculty Publications
Gonadotropin-releasing hormone 1 (GnRH1) and its receptor (GnRHR1) drive mammalian reproduction via regulation of the gonadotropins. Yet, a second form of GnRH (GnRH2) and its receptor (GnRHR2) also exist in mammals. GnRH2 has been completely conserved throughout 500 million years of evolution, signifying high selection pressure and a critical biological role. However, the GnRH2 gene is absent (e.g., rat) or inactivated (e.g., cow and sheep) in some species but retained in others (e.g., human, horse, and pig). Likewise, many species (e.g., human, chimpanzee, cow, and sheep) retain the GnRHR2 gene but lack the appropriate coding sequence to produce a full-length …
Epigenetic Profiling Of Mammalian Retrotransposons, Arundhati Bakshi
Epigenetic Profiling Of Mammalian Retrotransposons, Arundhati Bakshi
LSU Doctoral Dissertations
Over evolutionary time, mammalian genomes have accumulated a large number of retrotransposons, making up about half of the genome in any given species. These retrotransposons are typically repressed by epigenetic mechanisms, one of the main ones being DNA methylation. It is well known that improper DNA methylation of retrotransposons can have unwanted consequences on nearby gene expression, and hypomethylation of retrotransposons has been frequently observed in various cancers. Nevertheless, it has been notoriously difficult to study retrotransposon loci individually due to the highly repetitive nature of their sequences. To address this issue, we have developed a novel protocol termed HT-TREBS …