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Atrx Regulates H3.3 Incorporation And Gene Expression At G-Rich Ancestral Pseudoautosomal Genes, Michael A. Levy
Atrx Regulates H3.3 Incorporation And Gene Expression At G-Rich Ancestral Pseudoautosomal Genes, Michael A. Levy
Electronic Thesis and Dissertation Repository
Mutations in the ATRX gene cause alpha thalassaemia mental retardation, X linked, or can enable cancer progression. ATRX encodes a Swi2/Snf2 chromatin remodeling protein involved in deposition of the histone variant H3.3 at telomeres and pericentromeric heterochromatin. The aim of this study was to determine the role of ATRX in the regulation of gene expression. I identified the ancestral pseudoautosomal region (aPAR) genes as some of the most downregulated genes throughout forebrain development. The PARs are homologous regions located at the ends of the X and Y chromosomes, and are rich in repetitive sequences and GC content. However, mouse PAR …