Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Life Sciences
The Impact Of Host Factors On Retroviral Evolution And The Identification Of A Novel Receptor That Was Used By An Ancient Primate Retrovirus, Steven J. Soll
The Impact Of Host Factors On Retroviral Evolution And The Identification Of A Novel Receptor That Was Used By An Ancient Primate Retrovirus, Steven J. Soll
Student Theses and Dissertations
The resurrection of inactive endogenous retroviruses allows us to learn about interactions between extinct pathogens and their hosts that occurred millions of years ago. Two of these paleoviruses, chimpanzee endogenous retrovirus 1 and 2 (CERV1 and CERV2), are relatives of modern murine leukemia viruses that are found in the genomes of a variety of old world primates, but are absent from the human genome. The nonexistence of human CERV1 and CERV2 homologues is peculiar given the numerous apparent cross-species transmissions that occurred between ancestors of old world monkeys, gorillas, and chimpanzees. It is possible that antiviral proteins were able to …
Reconstitution And Characterization Of Human Endogenous Retrovirus-K, Young Nam Lee
Reconstitution And Characterization Of Human Endogenous Retrovirus-K, Young Nam Lee
Student Theses and Dissertations
Retroviruses are a family of clinically significant and scientifically fascinating viruses that infect a wide array of organisms from all vertebrate classes. The two hallmark events in the life cycle of retroviruses are the reverse transcription of the single stranded RNA (ssRNA) genome generating a double stranded DNA (dsDNA) and the integration of this dsDNA into the host genome. Because integration is irreversible and the infected cells are usually difficult to target for elimination in the host, the infection is generally permanent. HIV-1, the most important and well-studied member of all retroviruses, is the causative agent of acquired immune deficiency …
Identification And Characterization Of Apobec1 Mrna Editing Targets: A Transcriptomics Approach, Brad Randall Rosenberg
Identification And Characterization Of Apobec1 Mrna Editing Targets: A Transcriptomics Approach, Brad Randall Rosenberg
Student Theses and Dissertations
RNA editing is generally defined as the alteration of an RNA sequence from that encoded by the genome through nucleotide insertion, deletion or modification. The Apolipoprotein B mRNA Editing Catalytic polypeptide 1 (APOBEC1) cytidine deaminase is an mRNA editing enzyme that modifies a specific cytidine in the apolipoprotein B (apoB) transcripts of small intestine enterocytes. APOBEC1-mediated cytidine to uridine editing generates an inframe stop codon and results in translation of a truncated apoB isoform with distinct functions in lipid transport. Other physiological mRNA targets of APOBEC1 editing have remained largely unknown. This thesis presents the development of an RNA-Seq method …