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Multiple Fgf4 Retrocopies Recently Derived Within Canids, Kevin Batcher, Peter Dickinson, Kimberly Maciejczyk, Kristin Brzeski, Sheida Hadji Rasouliha, Anna Letko, Cord Drögemüller, Tosso Leeb, Danika Bannasch
Multiple Fgf4 Retrocopies Recently Derived Within Canids, Kevin Batcher, Peter Dickinson, Kimberly Maciejczyk, Kristin Brzeski, Sheida Hadji Rasouliha, Anna Letko, Cord Drögemüller, Tosso Leeb, Danika Bannasch
Michigan Tech Publications
Two transcribed retrocopies of the fibroblast growth factor 4 (FGF4) gene have previously been described in the domestic dog. An FGF4 retrocopy on chr18 is associated with disproportionate dwarfism, while an FGF4 retrocopy on chr12 is associated with both disproportionate dwarfism and intervertebral disc disease (IVDD). In this study, whole-genome sequencing data were queried to identify other FGF4 retrocopies that could be contributing to phenotypic diversity in canids. Additionally, dogs with surgically confirmed IVDD were assayed for novel FGF4 retrocopies. Five additional and distinct FGF4 retrocopies were identified in canids including a copy unique to red wolves (Canis rufus). The …