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Full-Text Articles in Life Sciences
Monkey-Based Research On Human Disease: The Implications Of Genetic Differences, Jarrod Bailey
Monkey-Based Research On Human Disease: The Implications Of Genetic Differences, Jarrod Bailey
Laboratory Experiments Collection
Assertions that the use of monkeys to investigate human diseases is valid scientifically are frequently based on a reported 90–93% genetic similarity between the species. Critical analyses of the relevance of monkey studies to human biology, however, indicate that this genetic similarity does not result in sufficient physiological similarity for monkeys to constitute good models for research, and that monkey data do not translate well to progress in clinical practice for humans. Salient examples include the failure of new drugs in clinical trials, the highly different infectivity and pathology of SIV/HIV, and poor extrapolation of research on Alzheimer’s disease, Parkinson’s …
Holding Back The Genes: Limitations Of Research Into Canine Behavioural Genetics, Diane Van Rooy, Elizabeth R. Arnott, Jonathan B. Early, Paul Mcgreevy, Claire M. Wade
Holding Back The Genes: Limitations Of Research Into Canine Behavioural Genetics, Diane Van Rooy, Elizabeth R. Arnott, Jonathan B. Early, Paul Mcgreevy, Claire M. Wade
Genetics Collection
Canine behaviours that are both desirable and undesirable to owners have a demonstrable genetic component. Some behaviours are breed-specific, such as the livestock guarding by maremmas and flank sucking seen in Dobermanns. While the identification of genes responsible for common canine diseases is rapidly advancing, those genes underlying behaviours remain elusive. The challenges of accurately defining and measuring behavioural phenotypes remain an obstacle, and the use of variable phenotyping methods has prevented meta-analysis of behavioural studies. International standardised testing protocols and terminology in canine behavioural evaluations should facilitate selection against behavioural disorders in the modern dog and optimise breeding success …