Open Access. Powered by Scholars. Published by Universities.®
- Discipline
-
- Immunology and Infectious Disease (5)
- Biology (4)
- Medicine and Health Sciences (4)
- Biochemistry, Biophysics, and Structural Biology (3)
- Cellular and Molecular Physiology (3)
-
- Physiology (3)
- Bioinformatics (2)
- Cancer Biology (2)
- Cell Biology (2)
- Cell and Developmental Biology (2)
- Medical Immunology (2)
- Medical Sciences (2)
- Microbiology (2)
- Molecular Biology (2)
- Molecular and Cellular Neuroscience (2)
- Neuroscience and Neurobiology (2)
- Pharmacology, Toxicology and Environmental Health (2)
- Allergy and Immunology (1)
- Animal Experimentation and Research (1)
- Animal Sciences (1)
- Bacteriology (1)
- Biochemistry (1)
- Biotechnology (1)
- Computational Biology (1)
- Diseases (1)
- Endocrinology (1)
- Genetics (1)
- Genetics and Genomics (1)
- Immunity (1)
- Institution
- Publication
- Publication Type
Articles 1 - 12 of 12
Full-Text Articles in Life Sciences
Stabilin Receptors Clear Lps And Control Systemic Inflammation, Fatima Cabral, Mustafa Al-Rahem, John Skaggs, Thushara A. Thomas, Naresh Kumar, Qian Wu, Paolo Fadda, Lianbo Yu, John M. Robinson, Jonghan Kim, Ekta Pandey, Xinghui Sun, Wael N. Jarjour, Murugesan V.S. Rajaram, Edward N. Harris, Latha P. Ganesan
Stabilin Receptors Clear Lps And Control Systemic Inflammation, Fatima Cabral, Mustafa Al-Rahem, John Skaggs, Thushara A. Thomas, Naresh Kumar, Qian Wu, Paolo Fadda, Lianbo Yu, John M. Robinson, Jonghan Kim, Ekta Pandey, Xinghui Sun, Wael N. Jarjour, Murugesan V.S. Rajaram, Edward N. Harris, Latha P. Ganesan
Department of Biochemistry: Faculty Publications
Lipopolysaccharides (LPSs) cause lethal endotoxemia if not rapidly cleared from blood circulation. Liver sinusoidal endothelial cells (LSEC) systemically clear LPS by unknown mechanisms. We discovered that LPS clearance through LSEC involves endocytosis and lysosomal inactivation via Stabilin-1 and 2 (Stab1 and Stab2) but does not involve TLR4. Cytokine production was inversely related to clearance/endocytosis of LPS by LSEC. When exposed to LPS, Stabilin double knockout mice (Stab DK) and Stab1 KO, but not Stab2 KO, showed significantly enhanced systemic inflammatory cytokine production and early death compared with WT mice. Stab1 KO is not significantly different from Stab DK in circulatory …
Energetic Cost And Physiological Trade-Offs, Heba A. Ali
Energetic Cost And Physiological Trade-Offs, Heba A. Ali
FIU Electronic Theses and Dissertations
Understanding how organisms allocate limited resources across physiological systems is a major challenge in biology. This study revealed that high energetic demand of electric signals of male electric fish (Brachyhypopomus gauderio) is matched by a metabolic trade-off with other cellular functions. We used thyroxine (T4) to modulate the fish’s signal metabolism, partitioned the energy budget pharmacologically, and measured energy consumption using oxygen respirometry. In males, total energy consumption was unchanged pre- and post-T4 treatment, while signal metabolism rose and the standard metabolic rate fell in an even trade-off. Total metabolism in females did the opposite. Under T4, the …
Energy Expenditure Across Immune Challenge Severities In A Lizard: Consequences For Innate Immunity, Locomotor Performance And Oxidative Status, Susannah S. French, Spencer Hudson
Energy Expenditure Across Immune Challenge Severities In A Lizard: Consequences For Innate Immunity, Locomotor Performance And Oxidative Status, Susannah S. French, Spencer Hudson
Browse all Datasets
Reptiles, like other vertebrates, rely on immunity to defend themselves from infection. The energetic cost of an immune response is liable to scale with infection severity, prompting constraints on other selfmaintenance traits if immune prioritization exceeds energy budget. In this study, adult male side-blotched lizards (Uta stansburiana) were injected with saline (control) or high (20 μg g−1 body mass) or low (10 μg g−1 body mass) concentrations of lipopolysaccharide (LPS) to simulate bacterial infections of discrete severities. The costs and consequences of the immune response were assessed through comparisons of change in resting metabolic rate (RMR), energy metabolites (glucose, glycerol, …
Identifying The Cell Composition And Clonal Diversity Of Supratentorial Ependymoma Using Single Cell Rna-Sequencing, James He
University Scholar Projects
Ependymoma is a primary solid tumor of the central nervous system. Supratentorial ependymoma (ST-EPN), a subtype of ependymomas, is driven by an oncogenic fusion between the ZFTA and RELA genes in 70% of cases. We introduced this fusion into neural progenitor cells of mice embryos via in utero electroporation of a non-viral binary piggyBac transposon system containing ZFTA-RELA. From preliminary data in the LoTurco lab, inducing the expression of ZFTA-RELA into different neural progenitor cells produces tumors of varying lethality and cellular composition. To define the cellular composition and subclonal diversity of ST-EPN tumors, we used single cell RNA-sequencing to …
Identifying The Cell Composition And Clonal Diversity Of Supratentorial Ependymoma Using Single Cell Rna-Sequencing, James He
Honors Scholar Theses
Ependymoma is a primary solid tumor of the central nervous system. Supratentorial ependymoma (ST-EPN), a subtype of ependymomas, is driven by an oncogenic fusion between the ZFTA and RELA genes in 70% of cases. We introduced this fusion into neural progenitor cells of mice embryos via in utero electroporation of a non-viral binary piggyBac transposon system containing ZFTA-RELA. From preliminary data in the LoTurco lab, inducing the expression of ZFTA-RELA into different neural progenitor cells produces tumors of varying lethality and cellular composition. To define the cellular composition and subclonal diversity of ST-EPN tumors, we used single cell RNA-sequencing …
The Roles Of Capsular Polysaccharides And Diet In The Immune Response To A Bacteroides Thetaiotaomicron Antigen, Samantha Hsieh
The Roles Of Capsular Polysaccharides And Diet In The Immune Response To A Bacteroides Thetaiotaomicron Antigen, Samantha Hsieh
Arts & Sciences Electronic Theses and Dissertations
The environment is well recognized to modulate immune responses within the intestinal mucosa in a general fashion. However, the connection between the effects of the environment on the immune response directed towards specific intestinal microbes is unclear. Progress in this area has been hampered by the lack of a model system in which the immune responses to a specific antigen in a gut symbiont can be examined. To this end, we developed a novel CD4+ T cell model, termed BθOM, that is specific for a dominant antigen in the gut symbiont Bacteroides thetaiotaomicron (B. theta). In this work, we use …
Temperature-Dependent Macrophage Activity In Rainbow Trout, Danica Mcgrevey
Temperature-Dependent Macrophage Activity In Rainbow Trout, Danica Mcgrevey
Biological Sciences Undergraduate Honors Theses
Fever is an essential component of the immune response. Fever enhances immune responses as well as creates an environment in which the body has advantages over pathogens. Macrophages are often the first cells that come in contact with pathogens, as they reside in tissues. They are important for their engulfment of pathogens that results in the digestion of the pathogen, but they also produce nitric oxide and cytokines that contribute to immune response in a variety of ways, including initiating adaptive immunity and directing the production and activity of other immune cells. We were curious about macrophages from other temperature …
Assessing The Durability Of The Immune Response Induced By Rivax®, A Ricin Subunit Vaccine, Hayley Lynn Novak
Assessing The Durability Of The Immune Response Induced By Rivax®, A Ricin Subunit Vaccine, Hayley Lynn Novak
Legacy Theses & Dissertations (2009 - 2024)
Assessing the performance and durability of the antibody response in animal models can assist in the development of biodefense vaccines. Ricin is one of the most toxic biological agents known and has been a public health issue for years. Since ricin is easily manufactured and a deadly toxin, rational vaccine design and immunotherapeutic optimization have been explored. RiVax® is a candidate subunit vaccine with a modified A-chain of ricin toxin that was formulated to remove ricin's biological activity. It is thought that RiVax® could serve as a prophylactic that would induce humoral- and cell-mediated immunological responses that elicit protective antigens …
Pathogenicity Of Staphylococcus Agnetis Associated With Lame Broilers With Osteomyelitis, Sura Faris Salih Zaki
Pathogenicity Of Staphylococcus Agnetis Associated With Lame Broilers With Osteomyelitis, Sura Faris Salih Zaki
Graduate Theses and Dissertations
We developed High Resolution Melt Analysis (HERMA) as a rapid and reliable molecular diagnostic assay for the detection and identification of the main bacterial species recovered from the blood and lesions of bacterial chondronecrosis with osteomyelitis (BCO) from the lame broilers at the University of Arkansas poultry research farm. Also, the present study confirms that raising young birds on suspended wire flooring has been proved to successfully induce lameness attributable to BCO with birds being more susceptible to bacteraemia than those that were raised on litter flooring. The newly described pathogen, Staphylococcus agnetis, has been reported to be overrepresented in …
The Riddle Of The Fetal Allograft, Rachel Tepper
The Riddle Of The Fetal Allograft, Rachel Tepper
The Science Journal of the Lander College of Arts and Sciences
The immunological paradox of nurturing a fetus with paternal antigens poses some perplexing questions. Peter Medawar, an immunologist, asked at a lecture, “How does the pregnant mother contrive to nourish within itself, for many weeks or months, a fetus that is an antigenically foreign body?” Researchers have since then struggled to answer this question. The research on this topic has led to a few general hypotheses that try to explain this phenomenon. The downregulation of T cells toward paternal alloantigens is an accepted hypothesis. Another hypothesis discusses the significance of the decidua and its ability to impair dendritic cells, which …
Effects Of Feeding Varying Levels Of Inoculated Compost On Productive Performance, Egg Quality Traits, Organoleptic Properties, And Immune Response Of Commercial Layers, Muhammad Irfan, Shahid Mehmood, Athar Mahmud, Aftab Ahmad Anjum
Effects Of Feeding Varying Levels Of Inoculated Compost On Productive Performance, Egg Quality Traits, Organoleptic Properties, And Immune Response Of Commercial Layers, Muhammad Irfan, Shahid Mehmood, Athar Mahmud, Aftab Ahmad Anjum
Turkish Journal of Veterinary & Animal Sciences
A study was conducted to evaluate the impact of varying dietary inoculated compost levels on production performance, egg quality traits, and immune response of white laying hens (LSL) during the peak production phase (28 to 40 weeks). For this purpose, a total of 270 birds were randomly distributed into 5 dietary groups with 6 replicates each in techno battery cages having 9 birds per replicate following completely randomized design. Experimental diets were comprised of an increasing level of inoculated compost (0, 3, 6, 9, and 12%) and each diet was balanced (iso-caloric and iso-nitrogenous). The control group birds fed a …
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Relationship Between Autoimmunity And Polyautoimmunity, David Schon
The Science Journal of the Lander College of Arts and Sciences
Autoimmune disease refers to a systemic immune response by the body against its own healthy tissue and cells. This results in various non-specific and systemic inflammatory processes that evolve into more than 100 individual diseases. Numerous biological similarities exist between the different pathophysiological pathways, including biochemical cascades and inflammasome mediators. This paper aims to investigate whether contracting one form of autoimmune disease can lead to the development of polyautoimmunity and multiple autoimmune syndrome. Scientists have identified chronic levels of high stress as a contributor to higher levels of C-reactive protein and several immune modulating interleukins, which can lead to both …