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Full-Text Articles in Life Sciences
Comprehensive Characterization Of 536 Patient-Derived Xenograft Models Prioritizes Candidatesfor Targeted Treatment., Hua Sun, Song Cao, R Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C Wendl, Sherri R Davies, Matthew H Bailey, Tina M Primeau, Jeremy Hoog, Jacqueline L Mudd, Dennis A Dean, Rajesh Patidar, Li Chen, Matthew A Wyczalkowski, Reyka G Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A Van Tine, Cynthia X Ma, Rebecca Aft, Katherine C Fuh, Julie K Schwarz, Jose P Zevallos, Sidharth V Puram, John F Dipersio, Nci Pdxnet Consortium, Brandi Davis-Dusenbery, Matthew J Ellis, Michael T Lewis, Michael A Davies, Meenhard Herlyn, Bingliang Fang, Jack A Roth, Alana L Welm, Bryan E Welm, Funda Meric-Bernstam, Feng Chen, Ryan C Fields, Shunqiang Li, Ramaswamy Govindan, James H Doroshow, Jeffrey A Moscow, Yvonne A Evrard, Jeffrey Chuang, Benjamin J Raphael, Li Ding, Carol J Bult, Peter N Robinson
Comprehensive Characterization Of 536 Patient-Derived Xenograft Models Prioritizes Candidatesfor Targeted Treatment., Hua Sun, Song Cao, R Jay Mashl, Chia-Kuei Mo, Simone Zaccaria, Michael C Wendl, Sherri R Davies, Matthew H Bailey, Tina M Primeau, Jeremy Hoog, Jacqueline L Mudd, Dennis A Dean, Rajesh Patidar, Li Chen, Matthew A Wyczalkowski, Reyka G Jayasinghe, Fernanda Martins Rodrigues, Nadezhda V Terekhanova, Yize Li, Kian-Huat Lim, Andrea Wang-Gillam, Brian A Van Tine, Cynthia X Ma, Rebecca Aft, Katherine C Fuh, Julie K Schwarz, Jose P Zevallos, Sidharth V Puram, John F Dipersio, Nci Pdxnet Consortium, Brandi Davis-Dusenbery, Matthew J Ellis, Michael T Lewis, Michael A Davies, Meenhard Herlyn, Bingliang Fang, Jack A Roth, Alana L Welm, Bryan E Welm, Funda Meric-Bernstam, Feng Chen, Ryan C Fields, Shunqiang Li, Ramaswamy Govindan, James H Doroshow, Jeffrey A Moscow, Yvonne A Evrard, Jeffrey Chuang, Benjamin J Raphael, Li Ding, Carol J Bult, Peter N Robinson
Faculty Research 2021
Development of candidate cancer treatments is a resource-intensive process, with the research community continuing to investigate options beyond static genomic characterization. Toward this goal, we have established the genomic landscapes of 536 patient-derived xenograft (PDX) models across 25 cancer types, together with mutation, copy number, fusion, transcriptomic profiles, and NCI-MATCH arms. Compared with human tumors, PDXs typically have higher purity and fit to investigate dynamic driver events and molecular properties via multiple time points from same case PDXs. Here, we report on dynamic genomic landscapes and pharmacogenomic associations, including associations between activating oncogenic events and drugs, correlations between whole-genome duplications …
Fos Rescues Neuronal Differentiation Of Sox2-Deleted Neural Stem Cells By Genome-Wide Regulation Of Common Sox2 And Ap1(Fos-Jun) Target Genes., Miriam Pagin, Mattias Pernebrink, Mattia Pitasi, Federica Malighetti, Chew Yee Ngan, Sergio Ottolenghi, Giulio Pavesi, Claudio Cantù, Silvia K Nicolis
Fos Rescues Neuronal Differentiation Of Sox2-Deleted Neural Stem Cells By Genome-Wide Regulation Of Common Sox2 And Ap1(Fos-Jun) Target Genes., Miriam Pagin, Mattias Pernebrink, Mattia Pitasi, Federica Malighetti, Chew Yee Ngan, Sergio Ottolenghi, Giulio Pavesi, Claudio Cantù, Silvia K Nicolis
Faculty Research 2021
The transcription factor SOX2 is important for brain development and for neural stem cells (NSC) maintenance. Sox2-deleted (Sox2-del) NSC from neonatal mouse brain are lost after few passages in culture. Two highly expressed genes, Fos and Socs3, are strongly downregulated in Sox2-del NSC; we previously showed that Fos or Socs3 overexpression by lentiviral transduction fully rescues NSC's long-term maintenance in culture. Sox2-del NSC are severely defective in neuronal production when induced to differentiate. NSC rescued by Sox2 reintroduction correctly differentiate into neurons. Similarly, Fos transduction rescues normal or even increased numbers of immature neurons expressing beta-tubulinIII, but not …
Synthesis Of Thresholds Of Ocean Acidification Impacts On Echinoderms, N. Bednaršek, P. Calosi, R. A. Feely, R. Ambrose, M. Byrne, Kit Yu Karen Chan, S. Dupont, J. L. Padilla-Gamiño, J. I. Spicer, F. Kessouri, M. Roethler, M. Sutula, S. B. Weisberg
Synthesis Of Thresholds Of Ocean Acidification Impacts On Echinoderms, N. Bednaršek, P. Calosi, R. A. Feely, R. Ambrose, M. Byrne, Kit Yu Karen Chan, S. Dupont, J. L. Padilla-Gamiño, J. I. Spicer, F. Kessouri, M. Roethler, M. Sutula, S. B. Weisberg
Biology Faculty Works
Assessing the vulnerability of marine invertebrates to ocean acidification (OA) requires an understanding of critical thresholds at which developmental, physiological, and behavioral traits are affected. To identify relevant thresholds for echinoderms, we undertook a three-step data synthesis, focused on California Current Ecosystem (CCE) species. First, literature characterizing echinoderm responses to OA was compiled, creating a dataset comprised of >12,000 datapoints from 41 studies. Analysis of this data set demonstrated responses related to physiology, behavior, growth and development, and increased mortality in the larval and adult stages to low pH exposure. Second, statistical analyses were conducted on selected pathways to identify …
Disruptive Technologies With Applications In Airline & Marine And Defense Industries, Randall K. Nichols, Hans C. Mumm, Wayne Lonstein, Suzanne Sincavage, Candice M. Carter, John-Paul Hood, Randall Mai, Mark Jackson, Bart Shields
Disruptive Technologies With Applications In Airline & Marine And Defense Industries, Randall K. Nichols, Hans C. Mumm, Wayne Lonstein, Suzanne Sincavage, Candice M. Carter, John-Paul Hood, Randall Mai, Mark Jackson, Bart Shields
NPP eBooks
Disruptive Technologies With Applications in Airline, Marine, Defense Industries is our fifth textbook in a series covering the world of Unmanned Vehicle Systems Applications & Operations On Air, Sea, and Land. The authors have expanded their purview beyond UAS / CUAS / UUV systems that we have written extensively about in our previous four textbooks. Our new title shows our concern for the emergence of Disruptive Technologies and how they apply to the Airline, Marine and Defense industries. Emerging technologies are technologies whose development, practical applications, or both are still largely unrealized, such that they are figuratively emerging into prominence …