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Articles 1 - 6 of 6
Full-Text Articles in Life Sciences
Regulation Of In Vitro And In Vivo Hepatic Stellate Cell Activation By The Ayrl Hydrocarbon Receptor, Shivakumar Rayavara Veerabhadraiah
Regulation Of In Vitro And In Vivo Hepatic Stellate Cell Activation By The Ayrl Hydrocarbon Receptor, Shivakumar Rayavara Veerabhadraiah
Boise State University Theses and Dissertations
Liver fibrosis is a pathological condition characterized by the excessive deposition of extracellular matrix material by activated hepatic stellate cells (HSCs). We recently reported that activation of the aryl hydrocarbon receptor (AhR), a ligand-activated transcription factor, with 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) increases HSC activation in vitro and in mouse models of experimental liver fibrosis. The goal of this project was to determine the mechanism by which AhR activation impacts HSC activation and the subsequent development of liver fibrosis. It is possible that HSCs are direct cellular targets for TCDD. Alternatively, TCDD could increase HSC activation indirectly by exacerbating hepatocyte damage …
Identification And Characterization Of Candidate Staphylococcus Aureus Antigens For Inclusion In A Multivalent Bovine Mastitis Vaccine, Danielle Scarbrough
Identification And Characterization Of Candidate Staphylococcus Aureus Antigens For Inclusion In A Multivalent Bovine Mastitis Vaccine, Danielle Scarbrough
Boise State University Theses and Dissertations
Bovine mastitis, inflammation typically caused by bacterial infection, is the most prevalent disease affecting the global dairy industry. Staphylococcus aureus remains one of the most important pathogens implicated in the disease and can persist within herds at subclinical levels. A preventative S. aureus bovine mastitis vaccine would substantially lessen costs associated with treatment and restore revenue lost due to decreased milk production. One such experimental vaccine is the IsdA-CTA2/B + ClfA-CTA2/B vaccine, containing the S. aureus antigens IsdA and ClfA , each fused to the nontoxic A2/B subunits of cholera toxin, which serves as …
Analytic Solutions For Diffusion On Path Graphs And Its Application To The Modeling Of The Evolution Of Electrically Indiscernible Conformational States Of Lysenin, K. Summer Ware
Boise State University Theses and Dissertations
Memory is traditionally thought of as a biological function of the brain. In recent years, however, researchers have found that some stimuli-responsive molecules exhibit memory-like behavior manifested as history-dependent hysteresis in response to external excitations. One example is lysenin, a pore-forming toxin found naturally in the coelomic fluid of the common earthworm Eisenia fetida. When reconstituted into a bilayer lipid membrane, this unassuming toxin undergoes conformational changes in response to applied voltages. However, lysenin is able to "remember" past history by adjusting its conformational state based not only on the amplitude of the stimulus but also on its previous …
Dimerization Of The Notch Intracellular Domain Results In Distinct Signaling Activity, Jacob Jeffery Crow
Dimerization Of The Notch Intracellular Domain Results In Distinct Signaling Activity, Jacob Jeffery Crow
Boise State University Theses and Dissertations
The Notch signaling pathway is a core component of multicellularity; enabling cells to directly communicate with both their neighbors and the surrounding microenvironment. These signals are translated directly through the Notch proteins, where a fragment of Notch transitions into the nucleus to act as a co-transcription factor, setting into motion a host of physiological responses. Commonly involved in pathways that define a cell’s identity and fate decisions, what appears to be a simplistic pathway instead exists in a state of high-tunability and strict control. Missteps in this pathway are generally embryonically lethal or lead to a suite of congenital disorders …
Analyzing Change-Of-Direction And The Laterally Resisted Split Squat: Incorporating A Lateral Vector Into The Single Leg Squat, Derek Maddy
Boise State University Theses and Dissertations
Improving change of direction (COD) with the use of strength training has led to mixed results. To date, the modified single leg squat (MSLS) and the bilateral squat (BS) have been successfully used to improve COD, with equal improvement. COD is primarily performed at a 45-75° frontal plane angle; however, the MSLS and BS are performed at a 90° frontal plane angle. Based on the force vector theory, it is proposed that a more mechanically similar strength training exercise, the Laterally Resisted Split Squat (LRSS), be used. The purpose of this study is to compare COD with the LRSS, MSLS, …
Genetic Analysis Of Invasive Populations Of Ventenata Dubia (Poaceae): An Assessment Of Propagule Pressure And Pattern Of Range Expansion In The Western United States, Inna Pervukhina-Smith
Genetic Analysis Of Invasive Populations Of Ventenata Dubia (Poaceae): An Assessment Of Propagule Pressure And Pattern Of Range Expansion In The Western United States, Inna Pervukhina-Smith
Boise State University Theses and Dissertations
Molecular markers prove to be an invaluable tool in assessing the introduction dynamics, pattern of range expansion, and population genetics of an invasive species. Ventenata dubia (Leers) Coss. (Aveneae; ventenata) is a diploid, primarily self-pollinating, annual grass native to Eurasia and Northern Africa. The grass has a detailed herbarium collection history in the western United States since its discovery in eastern Washington in 1952. Genetic analysis of 51 invasive populations (1636 individuals) of V. dubia, coupled with historical records, suggests moderate propagule pressure from multiple introductions, followed by local or regional range expansion. Enzyme electrophoresis detected nine multilocus genotypes …