Life Sciences Commons^™

Understanding Of Aerosol Transmission Of Covid 19 In Indoor Environments, Adama Barro, Cathal O'Toole, Jacob S. Lopez, Matthew Quinones, Sherene Moore

Publications and Research

Our reason for discussing severe acute respiratory syndrome corona virus 2 (SARS-CoV-2) or 2019 novel corona virus (Covid-19), is to understand its aerosol transmission characteristics in indoor spaces and to mitigate further spread of this disease by designing a new HVAC system. The problem that we are tackling is the spread of covid-19 droplets through aerosol transmission by looking at potential engineering solutions to the existing HVAC systems. The purpose is to eradicate the spread of the COVID-19 by testing indoor spaces in an effort to understand the effectiveness of ventilation controls. We believe that scientists and engineers have not …

A Guide To Freshwater Aquariums, Noah Savastano

Senior Honors Projects

The objective of this project was to create a complete guide, useful for someone of any aquarium expertise level, describing how to set up and care for an aquarium. This guide explains the science behind processes involved in setting up and maintaining an aquarium. It also educates the reader on how to properly prioritize the safety of the fish. A full text was first created including all relevant information gathered from scholarly texts and online sources. Original photographs were incorporated as a supplement to the text. Fish and aquatic plants were drawn to further illustrate the concepts that were described …

The Impact Of Hemp Cropping Systems On Soil Quality In Western Kentucky, Jack Eaker

Scholars Week

Recently, hemp farming systems are increasingly popular in Kentucky replacing tobacco cropping systems. However, the study on the impacts of hemp cropping on soil properties is rarely conducted, resulting in limited data on soil’s behavior/changes under these management practices. Therefore, the objective of this study was to determine soil characteristics including compaction, acidity level, moisture level, and water retention. The measurements were collected from three different hemp fields, three crop rotation studies ( in 2020 - corn, soybean and tobacco) and a bare field adjacent to these fields. All fields are located at Murray State University West Farm, Calloway County, …

The Nature Of Genes Expressed Differently After Environmental Drug Exposure, Nicci Siffel

Scholars Week

The Nature of Genes Expressed Differently after Environmental Drug Exposure

N. Siffel, S. Anderson, B. Subedi, D.R. Hammond-Weinberger

Drug use, of prescription or illicit varieties, alter bodily functions in different ways, especially in the nervous system. These drugs are found in sources of drinking water because they are not removed by wastewater treatment facilities. To investigate the effects of these drugs as they appear in mixtures, we exposed groups of zebrafish embryos to cocktails of drugs and screened for genes that were differentially expressed between the experimental and control groups and could thus give more insight into their biological functions. …

Evaluating The Impact Of Common Fertilizers On Soil Properties After Planting Tomatoes And Marigolds, Rachel Stuckey, Iin Handayani

Scholars Week

There are many name brand fertilizers that are used today in gardening in the state of Kentucky. Due to the standardization of name brand fertilizer production in factories, this can cause the fertilizers to compromise the nutrients of soil, while all-natural fertilizers are seen as better quality for the consumers, plants and soils. Alaska, Miracle Grow, Monty’s, Pure Gold, Tiger Bloom are the top five fertilizers sold in the state of Kentucky. This study aims to determine the impact of five top commercial fertilizers on soil quality indicators including organic matter, acidity level and moisture content. These fertilizers were applied …

Development Of “Sharkavir”: A New Hypothetical Inhibitor For Hiv-1 Protease, Feza Abbas

Trick to the Treat of Internships and Research

HIV has infected approximately 37 million people worldwide and results in over 1 million deaths annually. A key component of the HIV life cycle is the enzyme HIV-1 protease, which is involved in cutting newly made protein components of the HIV virion. Our research focused on how can molecular models be used to simulate the binding of various HIV-1 prtease inhibitors including Darunavir, Ritonavir, and a novel combination of these two named "Sharkavir".

Two And Three-Dimensional Radiographic Imaging Of Contrast Agents In Heterogeneous Live Cell Media To Understand Contrast-Induced Toxicity, Fahaneda Hassan, Aldona Gjoni, Subhendra Sarkar

Publications and Research

Radiographic imaging was done using low and high energy radiography equipment. The test hypothesis that macromolecular aggregation changes sample noise in imaging samples for optical imaging methods. Inorganic complexes scatter radiation at the molecular level and may increase the sample noise locally. At high and low photon energies in various x-ray machines, sample and background noise were gathered and compared with those from mammography systems from mammography researchers. The samples with high macromolecular aggregates were prepared using various animal cell compositions and imaged under different conditions that produced different macromolecular dynamics within the samples and thus different image-based sample noise. …

Variations In Slow-Wave Eeg And Working Memory Deficits During Letter Number Sequencing Task Post-Concussion, Morgan Sotoloff

Neuroscience Presentations

Concussions are associated with various types of consequences, both short-term and long-term: ranging from acute symptomatology, resting protocols, return-to-play decisions, and the lingering effects that have been found to have significant impacts on cognitive processes and function in many individuals several months post-concussion. Previous research has demonstrated that certain dimensions of executive function are especially susceptible to mild traumatic brain injury (mTBI), specifically working memory and attention. Studies that have previously utilized electroencephalography (EEG), have found that increased very low frequency oscillations (VLFO) are associated with a disruption of goal-oriented activities, difficulties in cognition, hyperactivity, and inattention in concussed individuals …

Presence Of Electron Donor/Acceptor Radiographic Contrast Media In Unusual Photosynthesis Environment Of Fresh Plant Cells: Near-Infrared And X-Ray Characterization, Tetiana Soloviova, Subhendra Sarkar, Amina Shahbaz, Aldona Gjoni

Publications and Research

Photosynthesis is a chemical process through which light energy is used to convert inorganic material (water and carbon dioxide) into organic molecules. Anaerobic photosynthesis, also known as anoxygenic photosynthesis, is the process by which certain bacteria use light energy to create organic compounds but do not adequately involve oxygen. In this experiment we are trying to influence photosynthesis (light and dark reactions: PS-I and PS-II by electron rich gadolinium/iodine complexes like Eovist and Isovue. We also performed X-ray and NIR reflection spectroscopy (NIRS) to measure Gd difusivity and PS-I/II infrared response. The results for X-ray (45kvp and 5 Mas ) …

Project Manager: Antibody Discovery At Distributed Bio, Pedro I. Justiniano

Creative Activity and Research Day - CARD

Antibody discovery platforms have opened a new frontier in therapeutic development. Distributed Bio has built antibody libraries that produce computationally optimized antibodies pre-engineered with therapeutically desirable traits such as humanness, high CDRH3 diversity, thermostability, and other molecular scaffolding proven to pass clinical trial requirements. One of their most popular libraries is the Super Human 2.0 library. This library analyzes billions of antibodies to find the most suited antibody to bind to a specific antigen target. / As a Project Manager intern at Distributed Bio, I have been helping to manage projects of different companies to provide them with a product …

Year Long Water Quality Analysis Of White Horn Brook, Kevin Dyer

Senior Honors Projects

KEVIN DYER (Marine Biology)

Year-long Analysis of the Water Quality of White Horn Brook

Sponsor: Thomas Boving (Geological Sciences)

Water is the foundation for all life on earth and is the most vital resource on this planet. Despite this, oceans and waterways all over the world are being polluted and exploited in ways detrimental to their fundamental hydrologic functions. For instance, excess nitrate levels can lead to eutrophication which gives rise to harmful algae blooms. Low pH can cause the breakdown of CaCO3 exoskeletons of organisms, such mollusks. High temperature variations are major stressors to living things and can cause …

Hives, Rachel Selvaraj '22, Nicolette Schmidling '22, Abigail Ryner '22

Student Leadership Exchange (SLX)

Bees are a capstone species and the world’s most important animal as ranked by the Royal Geographic Society in London. They play a key role in the production of many food products which certain communities may depend on; however, their population has rapidly been declining as of lately. Hives is an organization which takes this issue into extreme consideration. We believe that habitat restoration efforts for bees is the strongest way to make an impact. We will work with numerous local gardens to install our artificial bee homes. These homes are created solely from recyclable materials. Not only are our …

Biol 250: Snps Found In The Ptc (Bitter Tasting) Gene, Katelin Savage

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

No abstract provided.

Strategizing For Workplace Culture: Developing And Introducing A Diversity, Equity, And Inclusion Road Map, Melissa Watkinson

Salish Sea Ecosystem Conference

Organizations are familiar with developing a strategic plan to focus their work on achieving their mission and vision. A diversity, equity, and inclusion (DEI) road map, aligned with organizational values of DEI, is a strategic plan that defines DEI in your work: where you are starting, where you want to end up, and how you are going to get there. Washington Sea Grant (WSG) has developed a 10-year road map that includes 13 ambitious, but achievable goals that are aligned with tangible strategies and expected outcomes. The road map goals range in specificity; examples include “WSG is welcome and inclusive” …

Genetic Variance In Flocculin Protein Family, Sarah Dooley, Dale Beach

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

Yeast fermentation produces a number of commercially important products, most typically represented by alcoholic beverages. In craft breweries that do not use expensive filtration systems, selecting a yeast variety for fermentation can determine the clarity of the product from hazy Belgian pilsner to a crisp, clear American lager. Flocculation refers to a stress response behavior in yeast to group together (flocculate) in conditions like low sugar or high alcohol content as experienced at the end of fermentation. Higher levels of flocculation increase the clarity. The process of flocculation is genetically controlled through a series of complicated interactions and depends on …

Fact Or Myth: The Flu Can Be Caused By The Flu Vaccine, Arleigh Wood

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

To many, the flu vaccine seems like a threat to an otherwise healthy individual. People often get the flu after receiving the flu shot, which does not promote confidence in the general public. These and other reasonings have created a myth that the flu vaccine can cause the flu. Understanding how the vaccination is created and how it interacts with the immune system helps to realize why the flu vaccine cannot cause the virus. For the vaccine to work, adaptive immunity must be activated by the introduction of the viral particles in a safe manner. An effective immune response from …

Fighting Waste And Feeding People: Exploring The Context Of Campus Food Waste And Student Recovery Efforts, Sarah Becker, Max Stout, Maddie Kuklentz, Savona Cerra

Environment and Sustainability Presentations

Wismer on Wheels is dedicated to our mission of not only reducing food waste on campus, but also reducing food insecurity in our wider community. The work of our team of over 35 student volunteers reflects that dedication. This past year we became the official Food Recovery Network chapter for Ursinus, broadened outreach efforts on- and off-campus, and boosted food waste education, all while recovering unprecedented quantities of food. In this presentation, we celebrate the accomplishments of our dedicated volunteers while exploring deeper questions about food waste on the Ursinus campus. Why are we seeing such massive food recovery numbers …

Biol 488: The Assessment And Analyzation Of Threats To Marine Life And Habitats And Project Proposals To Combat These Threats., Reece Theakston

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

For overfishing I propose that periodically we slightly expand fish sanctuaries and modify regulations to allow populations more time and more areas to grow. For pollution, the areas of pollution should be sectioned and ranked, then starting with the highest priority areas start pollution cleanup with both man and machine. Once the pollution is collected, I propose that the use of plastic eating bacteria and caterpillars be implemented to further break pollution down. In regard to habitat destruction I think the best approach is to treat the areas like a garden, plant new seeds, give them the nutrients and support …

Biol 488: Overview Of Health Consequences In The Ketogenic Diet And Efficacy In Treating Type-2 Diabetes, Talbot Thames

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

The ketogenic diet is an increasingly popular tool for weight loss. It has shown benefits for Type II Diabetes patients in reducing the use of medication for treatment and keeping blood glucose levels to manageable levels. This approach to diabetes management is stunted, however, due to a multitude of adverse effects such as acidosis and atherogenic risk factors. Dietary trials were performed to assess the efficacy of both diets in reducing blood glucose levels and other against the contemporary western diet, composed of a moderate-carbohydrate and moderate-fat macronutrient profile. Upon completion, diabetic subjects in both the high-carbohydrate and low ketogenic …

Puget Sound Vital Sign Revision: Objectives For Puget Sound Recovery And Protection, Ron Thom

Salish Sea Ecosystem Conference

Since the mid-1980’s, there have been focused federal, state and local efforts to restore the Puget Sound ecosystem. Beginning in 2008 the Puget Sound Partnership (PSP) has produced Action Agendas that describe comprehensive recovery programs and, since 2011, have identified a set of Vital Signs and indicators. As of 2018, PSP identified 25 Vital Signs (VS) with 52 affiliated indicators. The PSP is now undertaking a collaborative effort to revise the VS and indicators to address known concerns and to situate them in a framework of other types of progress measures. Revised VS and indicators will characterize biophysical condition and …

Biol 250: Curly Hair Trait: Homozygous Or Heterozygous, Kaysi Bing

2020 Virtual Spring Student Showcase for Research and Creative Inquiry

Research Aim: To connect the SNP rs17646946 AG genotype and curly hair

Hypothesis: People expressing a GG genotype at the SNP rs17646946 are most likely to have the curly hair trait

Progress Presentation On The Proposed Function Of Protein 4diu Through Bioinformatics Analyses, Melissa Hoff

Biochemistry and Molecular Biology Presentations

The BASIL project is a scientific inquiry project that aims to determine the function of a protein from its structure. Biochemistry students completed wet lab work, while structural biology students worked in silico. The purpose of this study was to determine the function of the protein with PDB ID: 4DIU. Bioinformatics analyses were completed using several databases: BLAST, Dali, Pfam, and Moltimate, and imaging of the protein was completed using PyMOL software. The BLAST database aligned the primary sequence with known protein sequences. The Dali database compared protein structure with known structures through global alignment. The Pfam database matched our …

Reconstitution Efficiency On Elution Process, Brandon Winter, Landon Beachy, Samantha Stejskal, Zachary Rice

Scholar Week 2016 - present

Our group is presenting on the Reconstitution Efficiency on Elution Process for MilliporeSigma. The process that we are working with is the mixing of BAAP (Bovine Albumin Acetone Powder) into reverse osmosis water. This process is the first step of many in the making of medical test kits, of which include HIV/AID, strep throat, and pregnancy tests. Our initial task was to reduce the mixing time by 50%, however after further exploration of the problem, a more stable and consistent process turned into our primary goal and a significant reduction in time became a secondary goal. Initially, we were using …

The Classification Of An Unknown Protein 3h04, Britney Dyszel

Biochemistry and Molecular Biology Presentations

An unclassified protein in the Protein Data Bank, 3H04, was selected as a protein of interest. Research was performed in silico to gain key information on the structure, sequence, and homology of protein 3H04. This research was guided using the BASIL Project’s protocols on in silico research. Several databases were utilized to study protein 3H04. Based on the data gathered, unclassified protein 3H04 is an aminopeptidase that cleaves prolyl-dipeptidyl peptide bonds through alpha beta hydrolase function.

Computational Chemistry - Ulk 101, Michaela Montpas

Scholar Week 2016 - present

Autophagy is a process that generates the necessary building components for cells by cytoplasmic breakdown of unnecessary materials (Martin, Celano, Solitro, Gunaydin, Scott, et. al., 2018). This is a survival technique for cells in times of stress, especially during periods of nutrient starvation. Cancer cells, unfortunately, benefit from this process due to their ability to flourish in nutrient-starved environments, becoming resistant to therapy. The primary protein in mammals responsible for this process is a serine/threonine kinase called ULK 1 (unc-51 like autophagy initiating kinase 1). As such, inhibitors of ULK 1 can be used in cancer therapies in order to …

Great Bay Estuary Subtidal Seaweed And Seagrass Sampling Photographs 2019, David M. Burdick, Gregg Moore

Jackson Estuarine Laboratory

Led by Dr. Gregg Moore, cover of sub-tidal seaweed and eelgrass was sampled using remote video. Nine images were clipped for each of three sample areas (replicates) for four locations around Great Bay and herein is a record of the photographs.

Great Bay Estuary Intertidal Seaweed Plot Photographs 2019, David M. Burdick

Jackson Estuarine Laboratory

Records of photographs of intertidal seaweed sampling plots for cover (50 by 50 cm) and biomass (25 by 25 cm) collected by Jackson Estuarine Laboratory staff and volunteers in June, August and October 2019. Many of the photos were taken by Coastal Research Volunteers, a SeaGrant Extension project led by Wells Costello.

Constructing A Series Of Informative Videos And Building Social Media Platforms For Save One Soul Animal Rescue League, Cassandra Munroe

Senior Honors Projects

Approximately six million animals enter shelters each year. Of those six million animals, about two million are killed each year. Due to the lack of spaying and neutering and overcrowding, especially in the southern states of the U.S., the population of animals in high-kill shelters is alarming. Save One Soul Animal Rescue League (SOSARL) is a volunteer-driven non-profit dog rescue founded and based in Rhode Island. The mission of SOSARL is to permanently rehome homeless, neglected, abandoned, and at-risk dogs. The majority of the dogs rehomed by SOSARL are transported from overcrowded high-kill shelters in the Southern U.S. or from …

Germination And Early Seedling Growth Of Vegetables Under Various Salinity Stresses, Waqas Ahmad, Muhammad Haider Ali, Iin P. Handayani Dr., Brian Parr Dr.

Scholars Week

Vegetables are an important part of our daily diet. As salinity levels in soil and irrigation water have increased, biomass production of horticultural crops has been reduced during the past few years. The main objective of this study was to check the effect of different salinity levels (0mM, 25mM, 50mM, 100mM, 200mM NaCl) on the germination percentage and the growth rate of young seedlings of vegetables (tomato, turnip, onion, fenugreek and cauliflower) comprehensively. This experiment was designed through Factorial under Completely Randomize Design (CRD) and the results were analyzed through all Pair-wise comparison of means using Tukey test (P ≤ …

Pornography: Adolescent Brain Development & Addiction, William K. Canady

National Youth Advocacy and Resilience Conference

This presentation will explain the historical development of pornography. It will highlight three segments: 1- Porn’s impact on brain development of reward pathways, ultimately increasing the appetite for more porn. 2- Porn can be a false substitute for real intimacy, resulting in decreased sexual satisfaction with a real person and increased verbal and physical aggression. 3- Porn promotes sex trafficking, promotes multiple sex partners and reduced STD prevention.