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Articles 1 - 17 of 17
Full-Text Articles in Life Sciences
Acid Resistance Mechanisms In Staphylococcus Aureus, Chunyi Zhou
Acid Resistance Mechanisms In Staphylococcus Aureus, Chunyi Zhou
Theses & Dissertations
Staphylococcus aureus is a leading cause of opportunistic infections in community and health care settings. To thrive in a great variety of environments, S. aureus has developed the capability of tolerating temporary pH changes, as well as resisting constant acid stress. To evaluate the impact of strong and weak acid stress on S. aureus, growth patterns of JE2 were monitored when cultured in chemically defined media (CDM) at various pH in the presence of hydrochloric acid (HCl), acetic acid, and lactic acid. Our results showed that S. aureus responds to strong and weak acids in different manners. S. aureus …
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Polytechnic Journal
A particle of zinc sulfide (ZnS) was synthesized by the chemical coprecipitation method using zinc sulfate heptahydrate (ZnSO4), ammonium sulfate (NH4)2SO4 as a reactant, and thiourea as a stabilizer and capping agent. The optioned product characterized by electron dispersive X-ray spectroscopy that exhibits the presence of Zn and S elements. The average particle size of the ZnS nanoparticles determined using X-ray diffraction is about 4.9 nm. The ultraviolet–visible spectroscopy showed the blue shift in wavelength and the band gap was 4.33 eV, the surface morphology of the synthesized ZnS nanoparticles powder was studied by scan electron microscopy which was showed …
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Polytechnic Journal
A particle of zinc sulfide (ZnS) was synthesized by the chemical coprecipitation method using zinc sulfate heptahydrate (ZnSO4), ammonium sulfate (NH4)2SO4 as a reactant, and thiourea as a stabilizer and capping agent. The optioned product characterized by electron dispersive X-ray spectroscopy that exhibits the presence of Zn and S elements. The average particle size of the ZnS nanoparticles determined using X-ray diffraction is about 4.9 nm. The ultraviolet–visible spectroscopy showed the blue shift in wavelength and the band gap was 4.33 eV, the surface morphology of the synthesized ZnS nanoparticles powder was studied by scan electron microscopy which was showed …
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Polytechnic Journal
A particle of zinc sulfide (ZnS) was synthesized by the chemical coprecipitation method using zinc sulfate heptahydrate (ZnSO4), ammonium sulfate (NH4)2SO4 as a reactant, and thiourea as a stabilizer and capping agent. The optioned product characterized by electron dispersive X-ray spectroscopy that exhibits the presence of Zn and S elements. The average particle size of the ZnS nanoparticles determined using X-ray diffraction is about 4.9 nm. The ultraviolet–visible spectroscopy showed the blue shift in wavelength and the band gap was 4.33 eV, the surface morphology of the synthesized ZnS nanoparticles powder was studied by scan electron microscopy which was showed …
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Synthesis Of Zinc Sulfide Nanoparticles By Chemical Coprecipitation Method And Its Bactericidal Activity Application, Rebaz A. Omar, Karzan Abdul-Kareem Omar, Aqeel Ismael Gheni, Rekar Q. Ahmad, Sheyma M. Salih
Polytechnic Journal
A particle of zinc sulfide (ZnS) was synthesized by the chemical coprecipitation method using zinc sulfate heptahydrate (ZnSO4), ammonium sulfate (NH4)2SO4 as a reactant, and thiourea as a stabilizer and capping agent. The optioned product characterized by electron dispersive X-ray spectroscopy that exhibits the presence of Zn and S elements. The average particle size of the ZnS nanoparticles determined using X-ray diffraction is about 4.9 nm. The ultraviolet–visible spectroscopy showed the blue shift in wavelength and the band gap was 4.33 eV, the surface morphology of the synthesized ZnS nanoparticles powder was studied by scan electron microscopy which was showed …
The Role Of Secreted Proteases In Regulating Disease Progression In Staphylococcus Aureus, Brittney D. Gimza
The Role Of Secreted Proteases In Regulating Disease Progression In Staphylococcus Aureus, Brittney D. Gimza
USF Tampa Graduate Theses and Dissertations
Staphylococcus aureus is a highly successful pathogen capable of producing a wealth of virulence factors in the human host. Of note, ten extracellular proteases are produced alongside these virulence factors and play a multifaceted role during infection. They not only cleave host proteins to promote bacterial invasion, immune evasion and survival, but also control disease progression by modulating the stability of self-derived pathogenic determinants. The importance of the secreted proteases modulating virulence factor stability is evidenced by our groups previous finding that a protease-null strain has a substantially increased infectious capacity in a murine model of sepsis; resulting from the …
A Research Of Some Pathogen Microorganisms In Traditional Sharri Cheese, Ali Aydin, Endra Luzha
A Research Of Some Pathogen Microorganisms In Traditional Sharri Cheese, Ali Aydin, Endra Luzha
UBT International Conference
Sharri cheese is a traditional hard, fatty and salty type of cheese produced in Sharri, Gora, Opoja and Shtirpca towns in the Sharr Mountains region. Sharri cheese is produced by processing sheep milk, cow milk or their mixture. The aim of this study was to determine the microbiological quality of traditionally and industrially produced Sharri cheese. In total 58 samples of cheese were examined. Staphyloccocus aureus was positive in 57 samples. In a research for Eschericia coli, 34 samples showed result from 1x10¹/mL to 4.5x10⁶/mL. According to our results, Sharri cheese can carry risk for foodborne pathogens and these …
Siderophore-Dependent Transport Paradigms For Iron Across The Bacterial Cell Envelope In The Human Pathogen Staphylococcus Aureus, Nathaniel Endicott
Siderophore-Dependent Transport Paradigms For Iron Across The Bacterial Cell Envelope In The Human Pathogen Staphylococcus Aureus, Nathaniel Endicott
Arts & Sciences Electronic Theses and Dissertations
This work is focused on iron trafficking through ABC transporters in Staphylococcus aureus and combatting the growing antimicrobial resistance crisis by exploiting virulence factors as therapeutic targets. Specifically, the goal was to understand the role of a siderophore-binding lipoprotein FhuD2 in S. aureus iron trafficking. While S. aureus endogenously produces three metallophores for metal sequestration from the host, FhuD2 is thought to scavenge metals from hydroxamate-based xenosiderophores encountered in the host environment. FhuD2 is a critical virulence factor and vaccine candidate (Novartis) for MRSA. Since xenosiderophore scavenging systems are often dispensable, it was hypothesized that FhuD2 must be playing another …
Siderophore-Dependent Transport Paradigms For Iron Across The Bacterial Cell Envelope In The Human Pathogen Staphylococcus Aureus, Nathaniel Endicott
Siderophore-Dependent Transport Paradigms For Iron Across The Bacterial Cell Envelope In The Human Pathogen Staphylococcus Aureus, Nathaniel Endicott
Arts & Sciences Electronic Theses and Dissertations
This work is focused on iron trafficking through ABC transporters in Staphylococcus aureus and combatting the growing antimicrobial resistance crisis by exploiting virulence factors as therapeutic targets. Specifically, the goal was to understand the role of a siderophore-binding lipoprotein FhuD2 in S. aureus iron trafficking. While S. aureus endogenously produces three metallophores for metal sequestration from the host, FhuD2 is thought to scavenge metals from hydroxamate-based xenosiderophores encountered in the host environment. FhuD2 is a critical virulence factor and vaccine candidate (Novartis) for MRSA. Since xenosiderophore scavenging systems are often dispensable, it was hypothesized that FhuD2 must be playing another …
Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace
Antibiotic Drug Discovery Targeting Bacterial Metabolism, Miranda J. Wallace
Theses and Dissertations (ETD)
Over the last century, the use of antibiotics has enabled many advances in modern medicine, making life as we know it possible. In recent years, however, emerging bacterial resistance to virtually all major antibiotic classes has resulted in a worldwide increase in morbidity, mortality, and financial burden associated with drug resistant infections. The antimicrobial resistance crisis presents an urgent need for new antimicrobials with distinct mechanisms of action from existing drugs. The current pharmaceutical pipeline of new antibiotics is limited due to three obstacles: a lack of understanding of resistance mechanisms, a dearth of novel mechanisms of action among new …
The Signature Of God In Medicine And Microbiology An Apologetic Argument For Declarative Design In The Discoveries Of Alexander Fleming, Alan L. Gillen, Michael Cargill
The Signature Of God In Medicine And Microbiology An Apologetic Argument For Declarative Design In The Discoveries Of Alexander Fleming, Alan L. Gillen, Michael Cargill
Alan L. Gillen
In logic and reasoning, a signature indicates the presence of an author; likewise, the characteristics of staphylococci indicate the presence of a Creator. Staphylococci and its “kind” are common bacteria, particularly in colonized people.1 Staphylococcus aureus has a complex molecular mechanism of assembling its golden pigment, staphyloxanthin. The biosynthesis of staphyloxanthin is a stellar example of irreducible complexity. Similar to staphylococci, the life and works of Alexander Fleming show the fingerprints of Providence. The so-called “serendipitous” achievements of Fleming have contributed to modern medicine, convincing Fleming and others that God was at work in his life. Fleming recognized that …
High Mrsa Carriage Rate Among Nursing Microbiology Students, Alan Lee Gillen, Whitney O. Daycock, Andrew Serafin
High Mrsa Carriage Rate Among Nursing Microbiology Students, Alan Lee Gillen, Whitney O. Daycock, Andrew Serafin
Alan L. Gillen
Staphylococcus aureus is a common cause of disease, particularly in colonized persons. Although methicillin-resistant S. aureus (MRSA) infections have become increasingly reported, populationbased studies of students preparing for the health professions having S. aureus and MRSA colonization are lacking. We have found that students in microbiology classes having more contact with individuals in a healthcare setting are more likely to carry MRSA in their nares and axilla. The classes who had the highest rate of MRSA carriage during the school year, 2013-2014, were those with nursing students, who had a greater exposure to clinical settings and nursing homes. The class …
Combating Drug Resistance - Comparison Of The Antibiotic Effect Of Hydrastis Canadensis Extract And Pure Berberine Via Minimum Inhibitory Concentration Assay, William Luke Scott, Timothy D. Trott
Combating Drug Resistance - Comparison Of The Antibiotic Effect Of Hydrastis Canadensis Extract And Pure Berberine Via Minimum Inhibitory Concentration Assay, William Luke Scott, Timothy D. Trott
Research in Biology
Herbal medicines are a melee of complex organic chemicals, making it difficult to ascertain their direct mechanism of action. In contrast to mainstream pharmaceuticals, it is argued that herbal medicines are effective because of multiple constituents working synergistically. The complexity of herbal medicines may give them advantages over simpler pharmaceuticals in combating antibiotic resistant microbes, but these advantages can be difficult to quantitate. Popular literature frequently espouses the healing properties of herbal medicines, but many of these claims are not scientifically supported. Many gains could be realized in public health and medicine if more research was aimed at validating / …
The Small Rna Teg41 Regulates Expression Of The Alpha Phenol-Soluble Modulins And Is Required For Virulence In Staphylococcus Aureus, Rachel L. Zapf, Richard E. Wiemels, Rebecca A. Keogh, Donald L. Holzschu, Kayla M. Howell, Emily Trzeciak, Andrew R. Caillet, Kellie A. King, Samantha A. Selhorst, Michael J. Naldrett, Jeffrey L. Bose, Ronan K. Carroll
The Small Rna Teg41 Regulates Expression Of The Alpha Phenol-Soluble Modulins And Is Required For Virulence In Staphylococcus Aureus, Rachel L. Zapf, Richard E. Wiemels, Rebecca A. Keogh, Donald L. Holzschu, Kayla M. Howell, Emily Trzeciak, Andrew R. Caillet, Kellie A. King, Samantha A. Selhorst, Michael J. Naldrett, Jeffrey L. Bose, Ronan K. Carroll
Nebraska Center for Biotechnology: Faculty and Staff Publications
Small RNAs (sRNAs) remain an understudied class of regulatory molecules in bacteria in general and in Gram-positive bacteria in particular. In the major human pathogen Staphylococcus aureus, hundreds of sRNAs have been identified; however, only a few have been characterized in detail. In this study, we investigate the role of the sRNA Teg41 in S. aureus virulence. We demonstrate that Teg41, an sRNA divergently transcribed from the locus that encodes the cytolytic alpha phenolsoluble modulin (αPSM) peptides, plays a critical role in αPSM production. Overproduction of Teg41 leads to an increase in αPSM levels and a corresponding increase in …
Staphylococcus Aureus Evasion Of The Innate Immune System, James Paul Grayczyk
Staphylococcus Aureus Evasion Of The Innate Immune System, James Paul Grayczyk
Dissertations
Upon entry into the host, pathogens must overcome innate immunity in order to cause disease. The innate immune system represents a fast-acting initial line of defense to prevent infection. In order to withstand innate defenses, bacterial pathogens like the Gram-positive bacterium Staphylococcus aureus, produce a wide array of virulence factors that can inhibit innate immune cell recruitment and antimicrobial activity, or directly target and kill phagocytic leukocytes thereby facilitating pathogenesis. Infection with S. aureus can cause disease in virtually any tissue site and is a significant burden to human health. In this dissertation, we sought to understand how S. aureus …
Protection From Staphylococcus Aureus Bloodstream Infection By Probiotic Exopolysaccharide, Wonbeom Paik
Protection From Staphylococcus Aureus Bloodstream Infection By Probiotic Exopolysaccharide, Wonbeom Paik
Dissertations
Staphylococcus aureus is known to cause severe systemic infection with high mortality rates. Antibiotics are the only approved therapy for patients, but the widespread prevalence of antibiotic resistant strains limits treatment efficacy, and many patients succumb to the disease. Many probiotic agents are commercially available, but the mechanisms by which they benefit are not known. Understanding these mechanisms will help develop novel therapeutics that can improve healthcare, including systemic infections by S. aureus. Bacillus subtilis is a probiotic bacterium that produces an exopolysaccharide (EPS) that induces anti inflammatory macrophages (MΦ). We tested if EPS could be used for systemic S. …
Determination Of Growth And Toxin Production Potential Of Staphylococcus Aureus And Clostridium Perfringens During Döner Production Process, Funda Yilmaz Eker, Kami̇l Bostan
Determination Of Growth And Toxin Production Potential Of Staphylococcus Aureus And Clostridium Perfringens During Döner Production Process, Funda Yilmaz Eker, Kami̇l Bostan
Turkish Journal of Veterinary & Animal Sciences
Döner is a traditional meat meal that is commonly consumed in Turkey. Although it receives heat treatment during processing, some microorganisms including pathogens may remain alive. Therefore, this study was carried out to determine the changes in the number of microorganisms (total aerobic mesophilic bacteria, Enterobacteriaceae, Escherichia coli, aerobic mesophilic spore-forming bacteria, Staphylococcus-Micrococcus spp.) and survival potential of some pathogenic bacteria (Staphylococcus aureus and Clostridium perfringens) during the cooking period. Experimentally prepared döner kebabs were cooked continuously or intermittently. This process resulted in a reduction of microorganisms depending on the species and the use of low quality raw materials, and …