Open Access. Powered by Scholars. Published by Universities.®
- Publication
- Publication Type
Articles 1 - 2 of 2
Full-Text Articles in Life Sciences
Understanding The Influence Of The Cancer Microenvironment On Metabolism And Metastasis, Shonagh Russell
Understanding The Influence Of The Cancer Microenvironment On Metabolism And Metastasis, Shonagh Russell
USF Tampa Graduate Theses and Dissertations
Cancer is a complex and heterogeneous disease. Not only is there considerable variability between different cancer types, but there is enormous variability between and within patients who have the same type of cancer. Within tumors, there are multiple cell types, including cancer cells, stromal cells, and immune cells. The tumor microenvironment often induces the healthy cells to become pro-tumorigenic. Cell metabolism is exquisitely sensitive to changes in the tumor microenvironment and can be measured to infer the aggressiveness of cancer and predict response to therapy. In this dissertation, we aim to understand how the microenvironment, specifically low pH, affects the …
Use Of 3d Imaging For Providing Insights Into High-Order Structure Of Mitotic Chromosomes, Mohammad Yusuf, Kohei Kaneyoshi, Kiichi Fukui, Ian Robinson
Use Of 3d Imaging For Providing Insights Into High-Order Structure Of Mitotic Chromosomes, Mohammad Yusuf, Kohei Kaneyoshi, Kiichi Fukui, Ian Robinson
Centre for Regenerative Medicine & Stem Cell Research
The high-order structure of metaphase chromosomes remains still under investigation, especially the 30-nm structure that is still controversial. Advanced 3D imaging has provided useful information for our understanding of this detailed structure. It is evident that new technologies together with improved sample preparations and image analyses should be adequately combined. This mini review highlights 3D imaging used for chromosome analysis so far with future imaging directions also highlighted.