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The Role Of Dunc13 In Ethanol Tolerance, Yusuke Wachi
The Role Of Dunc13 In Ethanol Tolerance, Yusuke Wachi
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Although the effects of ethanol on presynaptic activity have been studied, the molecular mechanisms and the changes in gene expression which are responsible for inducing ethanol tolerance are unclear. Munc13-1 is an active-zone protein that is essential for presynaptic vesicle fusion. This protein interacts with vesicle fusion machinery at presynaptic active zones in the mammalian brain. The C1 domain of Munc13-1 binds diacylglycerol (DAG), which helps membrane localization of this protein and promotes vesicle fusion, facilitating synaptic vesicle release. Previously, it was shown that ethanol binds to the C1 domain of Munc13-1 in vitro at concentrations below 100 mM (Das …