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Full-Text Articles in Life Sciences
Investigating The Anti-Cancer Properties Of Novel Hybrid 1,4-Dihydropyridine Derivatives In U-87mg Glioblastoma Cell, Tendai Hunyenyiwa
Investigating The Anti-Cancer Properties Of Novel Hybrid 1,4-Dihydropyridine Derivatives In U-87mg Glioblastoma Cell, Tendai Hunyenyiwa
Master's Theses
Glioblastoma is the most devastating of brain cancers with a very high death rate and a low survival rate of less than 15 months after diagnosis. Glioblastoma is a cancer of astrocytes which are the majority of the brain glial cells that support neurons and help create the blood-brain barrier among other functions. The current approach to treating this disease is surgical removal of the main tumor, followed by radiotherapy and limited chemical intervention by the use of temozolomide (TMZ). This disease is characterized by high invasion and recurrence after surgical removal of the main tumor as a result of …
Synthesis And Screening Of Novel Hybrid Benzothiazoles In U-87 Mg Glioblastoma Cell Line, Priscilla Kyi
Synthesis And Screening Of Novel Hybrid Benzothiazoles In U-87 Mg Glioblastoma Cell Line, Priscilla Kyi
Master's Theses
Benzothiazole is a heteroaromatic compound known for its wide range of bioactivities including anti-cancer, anti-viral, anti-microbial, anti-inflammatory, anti-convulsant, anti-diabetic, anti-helminthic, and anti-tubercular activities. Research has shown that derivatives of benzothiazole exhibit inhibition of proliferation via apoptosis in various human cancer cell lines, such as liver cancer (Wang, et. al., 2011). In this study, a series of novel hybrid benzothiazole α-cyanostilbene derivatives and styrylbenzothiazole derivatives containing boronic acid and non-boronic acid pharmacophores were synthesized. The anti-cancer and anti-invasive properties of selected benzothiazole α-cyanostilbene derivatives on U-87MG glioblastoma cells were investigated in vitro.
U-87MG cells were incubated with synthesized novel hybrid compounds …