Life Sciences Commons^™

Investigating The Anti-Cancer Properties Of Novel Hybrid 1,4-Dihydropyridine Derivatives In U-87mg Glioblastoma Cell, Tendai Hunyenyiwa

Master's Theses

Glioblastoma is the most devastating of brain cancers with a very high death rate and a low survival rate of less than 15 months after diagnosis. Glioblastoma is a cancer of astrocytes which are the majority of the brain glial cells that support neurons and help create the blood-brain barrier among other functions. The current approach to treating this disease is surgical removal of the main tumor, followed by radiotherapy and limited chemical intervention by the use of temozolomide (TMZ). This disease is characterized by high invasion and recurrence after surgical removal of the main tumor as a result of …

Seasonal Diet Variation In Thirteen-Lined Ground Squirrel (Ictidomys Tridecemlineatus) In Southernwestern Michigan, Austin Menzmer

Master's Theses

Thirteen-lined ground squirrels (Ictidomys tridecemlineatus) are omnivorous ground squirrels that range from Texas to Alberta and from Michigan to Utah. The amount and type of both animal and plant matter in their diet may vary both geographically and seasonally. The present study was motivated by prior work, based on δ13C analysis of incisor enamel of thirteen-lined ground squirrels from a colony in southwestern Michigan, suggesting that these animals underwent a pronounced, late-season shift in diet from predominantly C3 to C4 plants. However, this inferred dietary shift was not directly demonstrated. Here, I tracked diet of thirteen-lined ground squirrels in southwestern …

Assessment Of Eastern Massasauga Rattlesnakes (Sistrurus Catenatus) In Berrien County Historical Sites, Roshelle M. Hall

Master's Theses

The Eastern Massasauga rattlesnake (Sistrurus catenatus; EMR) is a small robust pit viper currently found in nine states and the province of Ontario, Canada. Wetland habitats have experienced significant destruction and fragmentation by humans; as a result, the current distribution of the EMR is a fraction of its historic distribution. For this reason, the EMR has been federally listed as threatened. In general, little is known about the current distribution of this rattlesnake (in the southwest corner of Michigan, the size of local populations or their stability and genetic diversity. Much of this knowledge is based upon historical data. My …

Synthesis And Screening Of Novel Hybrid Benzothiazoles In U-87 Mg Glioblastoma Cell Line, Priscilla Kyi

Master's Theses

Benzothiazole is a heteroaromatic compound known for its wide range of bioactivities including anti-cancer, anti-viral, anti-microbial, anti-inflammatory, anti-convulsant, anti-diabetic, anti-helminthic, and anti-tubercular activities. Research has shown that derivatives of benzothiazole exhibit inhibition of proliferation via apoptosis in various human cancer cell lines, such as liver cancer (Wang, et. al., 2011). In this study, a series of novel hybrid benzothiazole α-cyanostilbene derivatives and styrylbenzothiazole derivatives containing boronic acid and non-boronic acid pharmacophores were synthesized. The anti-cancer and anti-invasive properties of selected benzothiazole α-cyanostilbene derivatives on U-87MG glioblastoma cells were investigated in vitro.

U-87MG cells were incubated with synthesized novel hybrid compounds …