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The Effect Of Dynamic Kinetic Selection On An Evolving Ribozyme Population, Patrick David Poletti

Dissertations and Theses

Dynamic Kinetic Selection (DKS) suggests that kinetic, rather than thermodynamic, stability will dictate the composition of a replicating population of biomolecules. Here, the results obtained from a series of five related reactions involving gradually increasing percentages of randomly-mutated substrate fragments to generate variants of full-length Azoarcus group I intron through an autocatalytic self-assembly reaction involving a series of recombination events, showed DKS as a driving factor in dictating the population composition of full-length product assembled from substrates that had fewer positions available to randomization.

In trying to elucidate a plausible scheme for the origins of complex biomolecules on the prebiotic …