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An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears
An Evolving Epigenome That Determines Tissue And Cell Specificity, Renee Louise Sears
Arts & Sciences Electronic Theses and Dissertations
Understanding the mechanisms driving phenotypic variation is a major goal of biology that unifies classical genetics with the emerging fields of genomics and epigenomics. Human and mouse share over 90% of genes and global tissue-specific patterns of expression are maintained between the species. Thus, it is hypothesized that gene expression is influenced through distinctive regulation among species in order to account for the unmistakable phenotypic divergence. DNA methylation, histone modifications, open chromatin patterns, transcription factor binding, and other epigenetic factors are all associated with shaping, maintaining, and repressing regulatory regions which in turn coordinate gene expression. It is vital to …