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Reactive Glutamines And A Binding Site Region Contribute To Fxiii Substrate Specificity For Fibrinogen Αc, Mohammed Hindi
Reactive Glutamines And A Binding Site Region Contribute To Fxiii Substrate Specificity For Fibrinogen Αc, Mohammed Hindi
College of Arts & Sciences Senior Honors Theses
The reaction between transglutaminase factor XIII (FXIII) and fibrin is a key process in the final stages of blood coagulation. The αC region of fibrin contains three reactive glutamines (Q237, Q328, and Q366) which are crosslinked by FXIII, as well as a FXIII anchoring site (E396). Previous work has helped elucidate the FXIII-αC interaction, but much is still unknown about the key residues in the αC region.
Four crosslinking assays were carried out to characterize the contribution of the αC anchoring site and reactive glutamines in crosslinking by FXIII. The effects of individual E396A, Q366N, and Q328P (Fibrinogen Seoul II …