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Macrophage Infiltration And Activation In Old And Young Skeletal Muscle Following Lengthening Contractions, Jamie P. Kaluhiokalani, Jacob R. Sorensen, Robert D. Hyldahl
Macrophage Infiltration And Activation In Old And Young Skeletal Muscle Following Lengthening Contractions, Jamie P. Kaluhiokalani, Jacob R. Sorensen, Robert D. Hyldahl
Library/Life Sciences Undergraduate Poster Competition 2019
•Human skeletal muscle is capable of robust regeneration following damage. •Muscle repair following injury is dependent on the timely activity of pro-inflammatory (M1) and anti-inflammatory, pro-regenerative (M2) macrophages. Following acute muscle injury, healthy skeletal muscle experiences a rapid and vigorous inflammatory response. •Macrophages clear necrotic tissue and facilitate satellite cell behavior through the secretion of cytokines and growth factors. •It is known that aged muscle experiences poor regenerative potential following injury, but the cause is not well-understood.
Purpose: The purpose of this study was to investigate macrophage behavior in old and young people in the context of muscle damage.
Hypothesis: …