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Full-Text Articles in Life Sciences
Elucidating The Mechanism Of Action Of Experimental Compound Sw33 In Toxoplasma Gondii, Sean Watson
Elucidating The Mechanism Of Action Of Experimental Compound Sw33 In Toxoplasma Gondii, Sean Watson
Theses/Capstones/Creative Projects
In recent years, antimicrobial drug resistance has become widespread and thus triggered an ever-growing need for the development of new, efficacious drug treatments. As an antimicrobial drug is developed, its mechanism of action is often identified before it becomes a potential candidate for clinical use. One potential method for identifying mechanism of action is chemical mutagenesis, in which induction of drug-resistant populations is followed by whole-genome sequencing of several clonal isolates. The subsequent observation of identical point mutations in the same gene across multiple drug-resistant populations can indicate a likely molecular target. However, this technique lacks the capacity to facilitate …
Visual Contributions To Balance Control During Gait, Kyle Brozek
Visual Contributions To Balance Control During Gait, Kyle Brozek
UNO Student Research and Creative Activity Fair
We propose to isolate the contributions of continuous OF to the orthogonal relationship between balance and gait control during treadmill walking using a series of conditions. Manipulating the direction of OF using a CAREN (Motek Medical, Amsterdam, Netherlands) virtual reality treadmill environment will isolate these visual contributions in human subjects as they walk. We plan to tease out the effect of OF direction on the relationship between gait and balance control by having healthy young adults perform a series of treadmill walking trials while immersed in a VR environment. This will be done by manipulating the direction of walking and …
Day To Day And Leg To Leg Variation In Gene Expression, Zohal Alizai
Day To Day And Leg To Leg Variation In Gene Expression, Zohal Alizai
UNO Student Research and Creative Activity Fair
BACKGROUND: Skeletal muscle biopsies are extensively used in research to determine the effects of exercise. Usually, sequential biopsies are taken before and after exercise in order to determine the influence of exercise on gene expression. Often it is not clear if the results are due to exercise or as a result of damage cause by the biopsy to the muscle. Previous studies have proven that multiple biopsies in the same leg cause stress to the muscle and such stress leads to inflammation and other response pathways that alter the gene expression. PURPOSE: The purpose of this study is to determine …