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Choline: Exploring The Growing Science On Its Benefits For Moms And Babies, Hunter W. Korsmo, Xinyin Jiang, Marie A. Caudill
Choline: Exploring The Growing Science On Its Benefits For Moms And Babies, Hunter W. Korsmo, Xinyin Jiang, Marie A. Caudill
Publications and Research
The importance of ensuring adequate choline intakes during pregnancy is increasingly recognized. Choline is critical for a number of physiological processes during the prenatal period with roles in membrane biosynthesis and tissue expansion, neurotransmission and brain development, and methyl group donation and gene expression. Studies in animals and humans have shown that supplementing the maternal diet with additional choline improves several pregnancy outcomes and protects against certain neural and metabolic insults. Most pregnant women in the U.S. are not achieving choline intake recommendations of 450 mg/day and would likely benefit from boosting their choline intakes through dietary and/or supplemental approaches.
Maternal Choline Supplementation Modulates Placental Markers Of Inflammation, Angiogenesis, And Apoptosis In A Mouse Model Of Placental Insufficiency, Julia H. King, Sze Ting (Cecilia) Kwan, Jian Yan, Xinyin Jiang, Vladislav G. Fomin, Samantha P. Levine, Emily Wei, Mark S. Roberson, Marie A. Caudill
Maternal Choline Supplementation Modulates Placental Markers Of Inflammation, Angiogenesis, And Apoptosis In A Mouse Model Of Placental Insufficiency, Julia H. King, Sze Ting (Cecilia) Kwan, Jian Yan, Xinyin Jiang, Vladislav G. Fomin, Samantha P. Levine, Emily Wei, Mark S. Roberson, Marie A. Caudill
Publications and Research
Dlx3 (distal-less homeobox 3) haploinsufficiency in mice has been shown to result in restricted fetal growth and placental defects. We previously showed that maternal choline supplementation (4X versus 1X choline) in the Dlx3+/�� mouse increased fetal and placental growth in mid-gestation. The current study sought to test the hypothesis that prenatal choline would modulate indicators of placenta function and development. Pregnant Dlx3+/�� mice consuming 1X (control), 2X, or 4X choline from conception were sacrificed at embryonic (E) days E10.5, E12.5, E15.5, and E18.5, and placentas and embryos were harvested. Data were analyzed separately for each gestational day controlling for litter …