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Articles 1 - 11 of 11
Full-Text Articles in Life Sciences
Cd147 As A Potential Therapeutic Target In Glioblastoma Treatment, Beau Adams
Cd147 As A Potential Therapeutic Target In Glioblastoma Treatment, Beau Adams
All NMU Master's Theses
Glioblastoma (GBM) tumors are the most common and lethal form of cancer in the central nervous system (CNS). GBM tumors appear to contain a mixture of different cell types, which makes them difficult to treat. GBM cells exhibit altered morphology from normal cells on several different levels, which highlights different pathways to potentially target for therapeutic treatments. The human surface glycoprotein CD147, also known as basigin, is expressed at significantly higher levels in GBMs compared to non-neoplastic brain tissue. Furthermore, levels of CD147 expression correlate with brain tumor progression and show the highest expression in GBM. Here, we suppressed tumor …
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
Characterization Of Theranostic Peptides For Glioblastoma Multiforme, Aaron Mellesmoen
All NMU Master's Theses
Glioblastoma multiforme (GBM) is a type of primary CNS tumor in which viable treatment options do not exist. Standard of care including tumor resection, chemotherapy, and radiation does little to extend the 5-year survival expectancy past 5.1%. Herein, two small-peptide molecules with inherent antitumor activity, blood-brain barrier permeability, and capability for tumor-specific drug deliverance and intraoperative visualization (termed theranostic) were of focus. Confocal microscopy was employed to characterize in vitro specificity of chlorotoxin, a 4 kDa scorpion venom peptide, and rBSG, the recombinant 25 kDa non-glycosylated extracellular domain of extracellular matrix metalloproteinase inducer (EMMPRIN; Basigin) isoform …
Ecological Drivers Of Plant Community Composition In A Patterned Fen At Seney National Wildlife Refuge, Michigan, Alex Graeff
Ecological Drivers Of Plant Community Composition In A Patterned Fen At Seney National Wildlife Refuge, Michigan, Alex Graeff
All NMU Master's Theses
Regional variation in geomorphology, vegetation, fen landforms, and water chemistry create a variety of unique peatlands across the Northern Hemisphere. In the Great Lakes region, patterned fens have been extensively studied in northern Minnesota, but largely ignored in Michigan. The purpose of this study was to describe vegetation, landforms, and water chemistry in a patterned fen at Seney National Wildlife Refuge. Percent cover of plant species and environmental variables were measured at 298 relevé style plots across 6 landform types: triangular swamp forests, featureless water tracks, peripheral water tracks, strings, flarks, and ponded sedge lawns. Additionally, several morphometric parameters were …
Climate Driven Range Shifts Of North American Small Mammals: Species’ Traits And Phylogenetic Influences, Katie Nehiba
Climate Driven Range Shifts Of North American Small Mammals: Species’ Traits And Phylogenetic Influences, Katie Nehiba
All NMU Master's Theses
Current anthropogenically-driven climate change is accelerating at an unprecedented rate. In response, species’ ranges may shift, tracking optimal climatic conditions. Species-specific differences may produce predictable differences in the extent of range shifts. I evaluated if patterns of predicted responses to climate change were strongly related to species’ taxonomic identities and/or ecological characteristics of species’ niches, elevation and precipitation. I evaluated differences in predicted range shifts in well-sampled small mammals that are restricted to North America: kangaroo rats, voles, chipmunks, and ground squirrels. I used species distribution modeling to develop predictions for the distributions of species under current and future climate …
Hypoxia-Regulated Expression Of Glut-1 In Gbm Cell Lines, Marissa Kane
Hypoxia-Regulated Expression Of Glut-1 In Gbm Cell Lines, Marissa Kane
All NMU Master's Theses
Unlike normal cells, cancer cells can grow in low oxygen (hypoxic) environments. Changes in relative oxygen concentration can alter gene expression in tumors to allow for their selective growth. The result of such changes allows the tumor to adapt its cellular metabolism and promote tumor progression. Most notably, hypoxic conditions induce expression of the transcription factor hypoxia inducible factor 1 (HIF-1). HIF-1 is thought to directly affect glucose transporter 1 (GLUT1) expression levels in hypoxic conditions. This study sought to determine the relationship between HIF-1 and GLUT1 expression levels within normoxic and hypoxic environments utilizing an in-vitro GBM model. The …
Compensatory Hip And Knee Mechanics In Transtibial Amputees During Stair Descent And Directional Task, Mindie Clark
Compensatory Hip And Knee Mechanics In Transtibial Amputees During Stair Descent And Directional Task, Mindie Clark
All NMU Master's Theses
This study compared lower limb mechanics in unilateral transtibial amputees and able bodied controls during strenuous activities of daily living (ADL). Seven unilateral transtibial amputee and five matched-abled bodied control participants executed stair descent on a four-step rehabilitation staircase followed by one of two anticipated directional tasks. Force, kinematics and gait parameters were chosen to compare mechanics and stride characteristics between the residual limb, intact limb and able-bodied dominant limb between a straight walking condition and a non linear directional movement (wide-step cutting task). Results indicated that significant compensatory mechanisms occurred in the intact limb, perhaps from decreased load tolerance …
Development Of A Rapid Diagnostic Assay For The Colorimetric Detection Of Bacterial And Viral Pathogens Using Loop-Mediated Isothermal Amplification Coupled With A Peptide Nucleic Acid And Gold Nanoparticle Reporter System, William Brown
All NMU Master's Theses
Detection of pathogenic agents remains pivotal to the control and prevention of infectious disease. While diagnostic methods continue to break barriers, the need for accurate, sensitive, and rapid methods persists. Current methods for pathogen detection, including culture, immunochemical, or molecular-based techniques, are subject to significant limitations that restrict their clinical utility. Point-of-care (POC) tests have received attention for the diagnostic screening of infectious disease, with benefits of simplicity, affordability, and convenience. This study describes the development of a novel loop-mediated isothermal amplification (LAMP) reaction followed by a peptide nucleic acid (PNA) probe and gold nanoparticle (AuNP) detection system that results …
Isolating And Identifying Fungal Endophytes From Roots Of Rare Orchid Cypripedium Arietinum In Grand Sable Dunes, Michigan, Kari Farkas-Lasich
Isolating And Identifying Fungal Endophytes From Roots Of Rare Orchid Cypripedium Arietinum In Grand Sable Dunes, Michigan, Kari Farkas-Lasich
All NMU Master's Theses
Recently the population of Cypripedium arietinum in Grand Sable Dunes, Michigan was estimated at more than 3.5 million plants, greater than 90% of the world’s known population. There is little research on this species’ root associated fungal endophytes. This new population estimate allows the ethical, destructive sampling required to shed light on root associated symbionts and further successful preservation and restoration of the species. Samples were collected of current year’s roots from 75 C. arietinum orchids at 75 locations within 4 jack pine forests in the Grand Sable Dunes, Pictured Rocks National Lakeshore, Michigan. Fungal endophyte cultures were obtained from …
Avian Foraging Response To Jack Pine (Pinus Banksiana) Volatile Chemicals, Katie Bjornen
Avian Foraging Response To Jack Pine (Pinus Banksiana) Volatile Chemicals, Katie Bjornen
All NMU Master's Theses
Birds benefit trees and other plants by removing herbivores that damage the plant and impede its growth. They can significantly increase the growth and biomass of the trees by foraging on the herbivores that harm plants, and the prey items eaten in turn benefits foraging birds by providing sustenance. This interaction becomes complex when tree volatile chemical communication is added. Trees regularly release volatile organic chemicals (referred to as VOCs) as part of metabolism. The particular VOCs released by a tree can depend on several factors, including water availability, time of year, and damage type (e.g., mechanical damage or insect …
The Characterization Of Behavioral Abnormalities In Bdnf Loxp Transgenic Mice, Ryan Brandt
The Characterization Of Behavioral Abnormalities In Bdnf Loxp Transgenic Mice, Ryan Brandt
All NMU Master's Theses
BDNF homozygous floxed mice (BDNF lox+/+) are a transgenic mouse strain used to study the neurotrophin brain-derived neurotrophic factor (BDNF) through Cre-Lox recombination when crossed with the appropriate Cre-expressing strain. BDNF lox+/+ mice contain two artificially inserted LoxP sites located upstream and downstream from the BDNF coding region. This strain was originally described as physiologically normal and fertile by Rios et al., (2001). However, current literature lacks sufficient characterization and description of its behavioral phenotype. We utilized a three-stage behavioral protocol which included home cage monitoring observations, open-field, tail suspension, and acoustic PPI to provide a detailed behavioral phenotype …
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol
Characterization Of The Roles Of Muscle-Synthesized Brain-Derived Neurotrophic Factor And Presynaptic Tyrosine Receptor Kinase B In Motor Neuron Axonal Transport, Luke A. Vanosdol
All NMU Master's Theses
Brain-derived neurotrophic factor (BDNF) is a small, diffusible protein essential for the development and function of neurons. It is synthesized by many types of tissue, including muscle. BDNF actions are mediated via binding to its receptor, tyrosine receptor kinase B (TrkB). The BDNF-TrkB complex is endocytosed into a specialized vesicle, which induces downstream signaling cascades locally in the dendrites, or, more often, is delivered to the cell soma via retrograde axonal transport, where it modulates gene expression. BDNF activation of TrkB is critical for the initiation of axonal transport, and this cellular process relies on the interaction of numerous adaptor …